Frontiers Media SA, ISBN: 978-2-88919-349-3 ebook
Edited by: Carsten Carlberg
195 pages
- 05 The Physiology of Vitamin D—Far More than Calcium and Bone,
Carsten Carlberg - 07 Genome-Wide (Over)View on the Actions of Vitamin D
Carsten Carlberg - 17 Structural Considerations of Vitamin D Signaling
Ferdinand Molnar - 39 Vitamin D and the RNA Transcriptome: More than mRNA Regulation
Moray J. Campbell - 52 Interaction of Vitamin D with Membrane-Based Signaling Pathways
Maria Jesus Larriba, Jose Manuel Gonzalez-Sancho, Felix Bonilla and Alberto Munoz - 62 Vitamin D and the Epigenome
Irfete S. Fetahu, Julia Hobaus and Eniko Kallay - 74 Tumor Suppression in Skin and Other Tissues Via Cross-Talk Between Vitamin D- and p53-Signaling
Joerg Reichrath, Sandra Reichrath, Kristina Heyne, Thomas Vogt and Klaus Roemer - 84 Vitamin D: A Critical and Essential Micronutrient for Human Health
Igor Bendik, Angelika Sonja johanna Friedel, Franz F Roos, Peter Weber and Manfred Eggersdorfer - 98 Impact of Vitamin D on Immune Function: Lessons Learned From GenomeWide Analysis
Rene F Chun, Philip T. Liu, Robert L. Modlin, John S Adams and Martin Hewison - 113 Vitamin D and Gene Networks in Human Osteoblasts,
Jeroen van de Peppel and Johannes PT.M.Van Leeuwen - 123 The Role of Vitamin D in Skeletal and Cardiac Muscle Function.
Patsie Polly and Timothy C. Tan - 130 Vitamin D and Adipose Tissue—More than Storage,
Shivaprakash J.Mutt, Elina Hypponen, Juha Saarnio, Marjo-Riitta Jarvelin and KarlHeinz Herzig, - 139 Vitamin D in Inflammatory Diseases,
Thea K. Wobke, Bernd L. Sorg and Dieter Steinhilber - 159 The Impact of Vitamin D in Breast Cancer: Genomics, Pathways, Metabolism,
Carmen Judith Narvaez, Donald Matthews, Erika LaPorta, Katrina Marie Simmons, Sarah Beaudin and JoEllen Welsh - 169 Vitamin D, Intermediary Metabolism and Prostate Cancer Tumor Progression,
Wei Lin W. Wang and Martin Tenniswood - 178 The Future of Vitamin D Analogs.
Carlien Leyssens, Lieve Verlinden and Annemieke Verstuyf
All of the PDF is attached below - in 3 sections
Section 1 PDF from Vitamin D Life
Section 2 PDF from Vitamin D Life
Section 3 PDF from Vitamin D Life
Tumor suppresson
Adipose.
Prostate Cancer Gene
The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, *iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.