Genes and Vitamin D – literature review – Dec 2015

Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: review of genetic association studies.

The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2015.12.007
David A Jolliffe, , Robert T Walton, Christopher J Griffiths, Adrian R Martineau a.martineau at qmul.ac.uk

Highlights
• We review a total of 120 genetic association studies on vitamin D pathway SNP
• Significant associations reported for a total of 55 SNP in 11 vit D pathway genes
• 44 studies report 114 findings of SNP which determine metabolite concentration
• 76 studies report 105 findings of SNP which affect non-skeletal health outcomes
• Infectious and auto-immune related disease were most frequent to associate with SNP
• Limited overlap of SNP predicting vit D status and SNP affecting disease outcomes

Polymorphisms in genes encoding proteins involved in vitamin D metabolism and transport are recognised to influence vitamin D status. Syntheses of genetic association studies linking these variants to non-skeletal health outcomes are lacking. We therefore conducted a literature review to identify reports of statistically significant associations between single nucleotide polymorphisms (SNP) in 11 vitamin D pathway genes (

• DHCR7,
• CYP2R1,
• CYP3A4,
• CYP27A1,
• DBP,
• LRP2,
• CUB,
• CYP27B1,
• CYP24A1,
• VDR and
• RXRA)

and non-bone health outcomes and circulating levels of 25-hydroxyvitamin D (25[OH]D and 1,25-dihydroxyvitamin D (1,25[OH]2D). A total of 120 genetic association studies reported positive associations, of which 44 investigated determinants of circulating 25(OH)D and / or 1,25(OH)2D concentrations, and 76 investigated determinants of non-skeletal health outcomes. Statistically significant associations were reported for a total of 55 SNP in the 11 genes investigated. There was limited overlap between genetic determinants of vitamin D status and those associated with non-skeletal health outcomes: polymorphisms in DBP, CYP2R1 and DHCR7 were the most frequent to be reported to associate with circulating concentrations of 25(OH)D, while polymorphisms in VDR were most commonly reported to associate with non-skeletal health outcomes, among which infectious and autoimmune diseases were the most represented.

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See also Vitamin D Life

Genetics category listing contains the following

266 articles in the Genetics category

see also

• 384 articles in Vitamin D Receptor
• 141 articles in Vitamin D Binding Protein = GC
• 35 articles in CYP27B1
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• Getting Vitamin D into your body

Vitamin D blood test misses a lot

• Snapshot of the literature by Vitamin D Life as of early 2019
• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
•    Commercially available 2019
  • However test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
  • especially if it is one of 51+ diseases related to Vitamin D Receptor
  
  2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
  3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
  • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
  
  4) Back Pain
  • probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
    • The founder of Vitamin D Life took action with clues #3&4

end of category listing