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First trimester Vitamin D deficiency in associated with placental inflammation, etc. – July 2018

Severe vitamin D deficiency in the first trimester is associated with placental inflammation in high-risk singleton pregnancy.

Clin Nutr. 2018 Jul 9. pii: S0261-5614(18)31197-X. doi: 10.1016/j.clnu.2018.06.978. [Epub ahead of print]
Zhang Q1, Chen H2, Wang Y1, Zhang C1, Tang Z1, Li H1, Huang X1, Ouyang F3, Huang H4, Liu Z5.

Vitamin D Life

This study considered just those women who associated with high risk pregnancies
Not clear if associated determination was made before or after pregnancy
Vitamin D deficiency level is defined as <11 ng in text, but < 8 ng in chart

Neonatal sepsis Fetal intrauterine infection
Placental Inflammation2.4 %15.6 %
No Placental Inflammation0.5 % 5.7 %

Typical vitamin D supplementation during pregnancy starts in middle of first trimester
It is unlikely that supplementation without loading dosing would provide much benefit during first trimester

See also Vitamin D Life

Grassroots Health May 2016

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

  • Vitamin D reduces sepsishas the following sections
    Infants with sepsis have very low Vitamin D levels – Aug 2014
    Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018
    Neonates 1.7 X more likely to get Sepsis if low vitamin D, mothers had low levels as well - July 2018


 Download the PDF from Vitamin D Life

Vitamin D deficiency during pregnancy is a worldwide epidemic. This study aimed to identify whether vitamin D deficiency in early pregnancy is associated with placental inflammation in high-risk pregnancy.

This study comprised 23,396 women who provided serum samples in the first trimester for vitamin D analysis from January 2015 to December 2016. Among them, 2648 women with high-risk pregnancy underwent placental pathologic examination. Women were divided into placental inflammation positive (PIP) and placental inflammation negative (PIN) groups based on placental pathology. Multivariate logistic regression was used to evaluate the relationship between vitamin D levels and placental inflammation.

We found that severe vitamin D deficiency in early pregnancy was associated with placental inflammation. Maternal vitamin D levels were significantly lower in the PIP group than those in the PIN group (P = 0.025). Compared with the highest quartile of vitamin D levels, risk for placental inflammation was significantly higher in women with extremely low vitamin D levels (<5th percentile; P = 0.012). The effect estimate was slightly decreased but still significant (P = 0.027) after adjusting for maternal age, gestational age at birth, birth weight, infant sex, and sample collection season. In addition, compared with the PIN group, the incidences of adverse neonatal outcomes, including sepsis (0.5% vs 2.4%) and fetal intrauterine infection (5.7% vs 15.6%), were significantly higher in the PIP group than that in the PIN group (P < 0.001).

CONCLUSIONS: Severe vitamin D deficiency in the first trimester is a risk factor for placental inflammation in high-risk pregnancy.

Created by admin. Last Modification: Monday July 23, 2018 16:41:46 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
10233 pregnancy loading dose.jpg admin 23 Jul, 2018 15:16 27.84 Kb 619
10232 high-risk pregnancy.jpg admin 23 Jul, 2018 15:09 27.57 Kb 365
10230 Low Vitamin D (less than 12 ng in first trimester) associated with high-risk pregnancies.rtf PDF 2018 admin 23 Jul, 2018 14:59 3.70 Kb 314
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