Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial
Diabetes Care 2017;40:872-878 | https://doi.org/10.2337/dc16-2302, accepted 11 April 2017
Hanne L. Gulseth,1,2 Cecilie Wium,1,2 Kristin Angel,3 Erik F. Eriksen,1,4 and Kare I. Birkeland1,4
1Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
2Hormone Laboratory, Oslo University Hospital, Oslo, Norway
3Department of Cardiology, Oslo University Hospital, Oslo, Norway
4Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Corresponding author: Hanne L. Gulseth, h.l.gulseth at medisin.uio.no.
Intervention group had < 40 ng by the end of the first month
Need to have > 40 nanograms for many months to treat diabetes
- Diabetes treated by vitamin D when levels exceeded 61 ng – Sept 2015
- Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017 Describes many low-cost gut-friendly forms of Vitamin D
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
454 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 49 ; Meta-analysis 28 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 34 ; Omega-3 10 ; Vitamin D Receptor 18 ; Genetics 10 ; Magnesium 18 Click here to see details Diabetes category starts with the following
454 items In Diabetes category see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has164 items along with related searches T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search Vitamin D Life for Peripheral Neuropathy 238 items April 2018
OBJECTIVE
In observational studies, low vitamin D levels are associated with type 2 diabetes (T2D), impaired glucose metabolism, insulin sensitivity, and insulin secretion. We evaluated the efficacy of vitamin D supplementation on insulin sensitivity and insulin secretion in subjects with T2D and low vitamin D (25-hydroxyvitamin D [25(OH) D] <50 nmol/L).RESEARCH DESIGN AND METHODS
Sixty-two men and women with T2D and vitamin D deficiency participated in a 6-month randomized, double-blind, placebo-controlled trial. Participants received a single dose of 400,000 IU oral vitamin D3 or placebo, and the vitamin D group received an additional 200,000 IU D3 if serum 25(OH)D was <100 nmol/L after 4 weeks. Primary end points were total Rd by euglycemic clamp with assessment of endogenous glucose production and first-phase insulin secretion by intravenous glucose tolerance test.RESULTS
In the vitamin D group, the mean ± SD baseline serum 25(OH)D of 38.0 ± 12.6 nmol/L increased to 96.9 ± 18.3 nmol/L after 4 weeks, 73.2 ± 13.7 nmol/L after 3 months, and 53.7 ± 9.2 nmol/L after 6 months. The total exposure to 25(OH)D during 6 months (area under the curve) was 1,870 ± 192 and 1,090 ± 377 nmol/L per week in the vitamin D and placebo groups, respectively (P < 0.001). Insulin sensitivity, endogenous glucose production, and glycemic control did not differ between or within groups after treatment (P = 0.52). First-phase insulin secretion did not change significantly after treatment (P = 0.10)CONCLUSIONS
Replenishment with a large dose of vitamin D3 to patients with T2D and vitamin D deficiency did not change insulin sensitivity or insulin secretion. These findings do not support such use of therapeutic vitamin D3 supplementation to improve glucose homeostasis in patients with T2D.PDF will be available free by Spring 2017
Diabetes not treated by single dose of vitamin D – RCT Aug 2017Printer Friendly PDF this page! Follow this page for updates1197 visitors, last modified 25 Aug, 2017, This page is in the following categories (# of items in each category)