Diabetes decreased in aged mice supplemented with vitamin D – April 2015

Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.

Biochem Biophys Res Commun. 2015 Apr 10. pii: S0006-291X(15)00674-9. doi: 10.1016/j.bbrc.2015.04.008. [Epub ahead of print]
Enciso PL1, Wang L2, Kawahara Y2, Sakamoto S2, Shimada S2, Takeichi Y2, Takayanagi R2, Nomura M3.
1Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan; Universidad Catolica Nuestra Señora de la Asunciòn, Independencia Nacional 176 y Comuneros C.C 1718, Asunción, Paraguay.
2Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan.
3Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan. Electronic address: nomura at med.kyushu-u.ac.jp.

Type 2 Diabetes is closely associated with our daily diets and has become a global health problem with an increasing number of patients. Recent observational and randomized studies on vitamin D3 suggested that higher plasma 25-hydroxyvitamin D3 [25(OH)D3] concentrations and more vitamin D3 intake are associated with lower risk of type 2 diabetes, which is characterized by postprandial hyperglycemia due to inappropriate glucose stimulated insulin secretion (GSIS) and its age-dependent increase of onset. However, rapid action of dietary vitamin D3 on the postprandial glucose profile has not been analyzed. When vitamin D3 is orally ingested in mice aged 12-14 weeks during an oral glucose tolerance test (OGTT), the serum glucose profile was not changed. In contrast, when OGTT was performed with old mice aged 30-34 weeks, the glucose profile was dramatically improved with increased insulin secretion, suggesting that orally ingested vitamin D3 potentiated GSIS in aged mice. Interestingly, there was also a significant increase in plasma GLP-1 in these aged mice. Our results suggest that orally ingested dietary vitamin D3 in aged mice improves glucose metabolism as a GLP-1 enhancer.

Copyright © 2015. Published by Elsevier Inc.
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PMID: 25869067

See also Vitamin D Life

• Overview Diabetes and vitamin D contains the following summary
• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 454 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• Appears that Calcium and Magnesium are needed for both Prevention and Treatment
  • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

• Dark Skin 22;   Intervention 49;   Meta-analysis 28;   Obesity 26;  Pregnancy 39;   T1 (child) 34;  Omega-3 10;  Vitamin D Receptor 18;  Genetics 10;  Magnesium 18    Click here to see details

Pages listed in BOTH the categories Diabetes and Seniors

See also web

• GLP-1 Wikipedia