Common drugs as vitamin D disruptors – 2020

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Journal of Translational Science doi: 10.15761/JTS.1000378

Uwe Gröber AMM - Academy of Micronutrient Medicine, Essen, Germany uwegroeber at gmx.net

In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.

PXR-Ligands	Examples
Antiepileptics	Phenytoin, carbamazepine
Antineoplastic drugs	Cyclophophamide, epirubicin, taxol, tamoxifen
Antibiotics	Clotrimazole, rifampicin
Anti-inflammatory agents	Dexamethasone
Antihypertensives	Nifedipine, spironolactone
Antiretroviral drugs	Efavirenz, ritonavir, saquinavir
Endocrine drugs	Cyproterone acetate

 Download the PDF from Vitamin D Life

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This study only looks at only one of the 6 genes that reduce Vitamin D getting to cells

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VitaminDwiki - Interactions with Vitamin D contains

Interactions with Vitamin D has 112 items

Various drugs decrease Vitamin D
Drugs that may harm bone (vitamin D needed) -April 2016
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Drugs which create a vitamin D deficiency
Antibiotics and Vitamin D are associated with many of the same diseases
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Plastics, BPA, PCB and Vitamin D deficiency
Smoking   Coffee
Cooked dried beans or peas

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See also CYP24A1 enzyme and Vitamin D - many studies