Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD
PLOS ONE: March 24, 2015DOI: 10.1371/journal.pone.0121622
Louise J. P. Persson , Marianne Aanerud, Pieter S. Hiemstra, Annika E. Michelsen, Thor Ueland, Jon A. Hardie, Pål Aukrust, Per S. Bakke, Tomas M. L. Eagan
Background: Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on longitudinal outcomes.
Methods: 426 COPD patients from western Norway, GOLD stage II-IV, aged 40–76, were followed every six-month from 2006 through 2009 with spirometry, bioelectrical impedance measurements and registration of exacerbation frequency. Serum 25(OH)D and VDBP levels were determined at study-entry by high-performance liquid chromatography coupled with mass spectrometry and enzyme immunoassays respectively. Yearly change in lung function and body composition was assessed by generalized estimating equations (GEE), yearly exacerbation rate by negative binomial regression models, and 5 years all-cause mortality by Cox proportional-hazard regression.
Results: 1/3 of the patients had vitamin D deficiency (<20ng/mL) and a greater decline in both FEV1 and FVC, compared to patients with normal levels; for FEV1 this difference only reached statistical significance in the 28 patients with the lowest levels (<10ng/mL, p = 0.01). Neither 25(OH)D nor VDBP levels predicted exacerbation rate, change in fat free mass index or risk of death.
Conclusion: Severe vitamin D deficiency may affect decline in lung function parameters in COPD. Neither 25(OH)D nor VDBP levels did otherwise predict markers of disease progression.
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- Search Vitamin D Life for COPD 338 items as of Dec 2014
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- COPD Overview
which has a chart of increased death rate due to COPD (age adjusted)