Benefits of Vitamin D often limited by genes

Vitamin D (Cholecalciferol in blood, fat, breast milk)
Processing by Liver into 'Calcidiol is limited by
        CYP24A1 gene
Outside of the liver Calcidiol' production is limited by
       CYP2R1 gene
Measured Vit D = Calcidiol

It seems that ~30% of the people do not get full benefit from Vitamin D due to gene limitations
It seems that 20% of limitations due to genes are invisible to Vitamin D blood tests

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Genetics has the following charts
Vitamin D blood test misses a lot


Click on chart for details

See also Vitamin D Life

• Vitamin D Binding Protein category listing has 141 items along with related searches
• Genetics category listing has 266 items along with related searches
• Health problems that run in families are often associated with low vitamin D
• Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
• Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
• Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014
• Common Vitamin D gene variants and resulting diseases – Jan 2013
• 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
• Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015
• Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
• 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015
• Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015

Vitamin D Receptor category has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement   Sun, Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D in the cells
13) Sulfroaphone and perhaps sulfur	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR