Low vitamin D serum levels as risk factor of Alzheimer’s disease: a systematic review and meta-analysis
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery https://doi.org/10.1186/s41983-023-00676-w
Rizaldy Taslim Pinzon, Theressia Handayani, Vincent Ongko Wijaya & Ranbebasa Bijak Buana
Past literatures have reported that changes in serum vitamin D levels are related to cognitive dysfunctions, such as dementia, including Alzheimer’s disease (AD). However, these past studies vary in results on whether vitamin D levels correlated with the development of AD. This meta-analysis aimed to assess the associations between low vitamin D serum levels as risk factor of AD based on the latest evidence. We systematically searched Pubmed and additional references for relevant articles according to PRISMA guidelines from the beginning up to December 2022. The risk estimate of AD was determined using a pooled hazard ratio (HR) with 95% confidence intervals (CIs). five prospective trials and one cross-sectional study were analyzed. The meta-analysis showed that patients with low vitamin D serum levels (< 25 ng/ml) had an increased risk of developing AD compared to patients with normal vitamin D levels (≥ 25 ng/ml) (HR: 1.59, 95% CI: 1.09, 2.33, I2=77%). Further research is required to provide evidence on whether maintaining sufficient vitamin D serum levels may lower the risk of AD.
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VitaminDWik Meta-analyses with ALZHEIMER in the title (13 as of July 2023)
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Vitamin D Life – Overview Alzheimer's-Cognition and Vitamin D contains
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in Vitamin D Life
There are 97+ Alzheimer’s studies in Vitamin D Life
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3