Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022

Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis

Front Aging Neurosci. 2022 Jan 10;13:799824. doi: 10.3389/fnagi.2021.799824.
Ke Du 1, Xi Zheng 1, Zi-Tai Ma 1, Jun-Ya Lv 1, Wen-Juan Jiang 1 2, Ming-Yan Liu 1

Alzheimer's disease (AD) remains a medical and social challenge worldwide. Magnesium (Mg) is one of the most frequently evaluated essential minerals with diverse biological functions in human body. However, the association between circulating Mg levels and AD remains controversial. We conducted a meta-analysis of 21 studies published between 1991 and 2021 to determine whether the Mg levels in the blood and cerebrospinal fluid (CSF) are abnormal in AD. Literatures were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data without language limitations.
A pooled subject sample including 1,112 AD patients and 1,001 healthy controls (HCs) was available to assess Mg levels in serum and plasma; 284 AD patients and 117 HCs were included for Mg levels in CSF. It was found that serum and plasma levels of Mg were significantly reduced in AD patients compared with HCs (standardized mean difference SMD = -0.89; 95% confidence interval [CI] [-1.36, -0.43]; P = 0.000). There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = -0.16; 95% CI [-0.50, 0.18]; P = 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = -0.74, 95% CI [-1.13; -0.35]; P = 0.000).
These results indicate that Mg deficiency may be a risk factor of AD and Mg supplementation may be a potentially valuable adjunctive treatment for AD.
Systematic Review Registration: www.crd.york.ac.uk/PROSPERO/, registration number CRD42021254557.

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Vitamin D Life - Magnesium and Vitamin D contains

• Overview Magnesium and vitamin D
• Magnesium deficiency – causes and symptoms – May 2016
• Vitamins and Metals needed by the Immune System – Jan 2020
• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
• Magnesium etc. reduced in crops (must supplement) – 2009
• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
• Magnesium is important for health but levels are low – July 2018
• Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018
• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol

Mg and Vitamin D

• Vitamin D and Magnesium need each other - many studies
• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
• Magnesium supplementation raises Vitamin D if initially less than 30 ng – RCT Dec 2018
• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
• Vitamin D Cofactors in a nutshell
• Magnesium and Vitamin D - similar, different and synergistic

Dr. Dean

• Some Podcasts by Dr. C Dean – Magnesium, Vitamin D, Iodine, etc.
• Magnesium and the body - depletion and reduced intake - Dean Oct 2019
• Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019

Number of studies in both of the categories of Magnesium and:

Vitamin D Life - Cognitive and Magnesium

Vitamin D Life - Cognitive category

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Vitamin D pages containing "Dementia" in title (40 as of April 2022)
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search Vitamin D Life for "WHITE MATTER" 53 items as of Jan 2017

Types of evidence that Vitamin D helps brain problems - 2014