6500 IU vitamin D not improve bone density without co-factors – Jan 2012

The effect of high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass--a randomized controlled 1-year trial.

Osteoporos Int. 2012 Jan;23(1):201-11. Epub 2011 Sep 10.
Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almås B, Jorde R.
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway. guri.grimnes at unn.no
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Observation by Vitamin D Life

Included Calcium, but not Magnesium, Vitamin K2, Strontium, etc. essential for building bones

See also Vitamin D Life

• All items in Bone Health and Vitamin D 269 items
• Vitamin D in schools helped bones, adding Calcium helped some – April 2012
• Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012
• Bone Health and vitamin D book - 2011
• Vitamin D is the first of three ways to make unbreakable bones – Oct 2011
• Calcium (alone) does not reduce risk of bone fracture
• Overview Osteoporosis and vitamin D
• Overview Bone fractures and vitamin D
• Overview Falling, Fractures and Vitamin D
• Bisphosphonates 4.5 X more likely to work when vitamin D level above 33 ng – Sept 2011
• Osteoporosis medication 7X better when more than 33 ng of vitamin D – June 2011
• Vitamin K and Vitamin D
  Includes problems with excess Calcium at end of page
• Overview Fractures and vitamin D
• Must balance cofactors when increasing vitamin D

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Vitamin D is widely used in osteoporosis treatment, although the optimal dose is not known. This 1-year clinical study among 297 women aged 50-80 years old showed that a vitamin D(3) dose of 6,500 IU/day was not better than the standard dose of 800 IU/day in improving bone mineral density (BMD) in the hip and spine.

INTRODUCTION:
The purpose of this study was to determine whether a high dose of vitamin D(3) was better than the standard dose in improving BMD and reducing bone turnover in postmenopausal women with reduced bone mass.

METHODS:
The study was a 1-year randomized double-blind controlled trial comparing high-dose vitamin D(3) with the standard dose. Postmenopausal women (n = 297) with a BMD T-score ? -2.0 in either lumbar spine (L2-4) or total hip were included and randomized to 6,500 IU vitamin D(3)/day (20,000 IU twice per week + 800 IU/day) or 800 IU vitamin D(3)/day (placebo twice per week + 800 IU/day).
Both groups were given 1,000 mg elemental calcium/day.
The primary endpoint was a change in BMD in total hip and lumbar spine (L2-4).

RESULTS:
After 1 year, serum 25-hydroxyvitamin D (25(OH)D) increased mean (SD) from 71 (23) to 185 (34) nmol/l and from 71 (22) to 89 (17) nmol/l in the high- and standard-dose vitamin D groups, respectively. BMD at all measurement sites was unchanged or slightly improved with no significant differences between the groups. Although bone turnover was reduced in both groups, the more pronounced reduction in serum levels of the bone formation marker P1NP in the standard-dose group may indicate that this treatment was more efficient. Adverse events did not differ between the groups.

CONCLUSIONS:
One year treatment with 6,500 IU vitamin D(3)/day was not better than 800 IU/day regarding BMD in vitamin D-replete postmenopausal women with reduced bone mass and was less efficient in reducing bone turnover.

Comment in Osteoporos Int. 2012 Feb;23(2):789-90 Heaney RP.; author reply 791.

PMID: 21909730