Pancreatic cancer 80 percent more likely if person had diabetes for 2-8 years – Jan 2013

Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium

Cancer Causes & Control, January 2013, Volume 24, Issue 1, pp 13-25
Joanne W. Elena, Emily Steplowski, Kai Yu, Patricia Hartge, Geoffrey S. Tobias, Michelle J. Brotzman, Stephen J. Chanock, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, H. Bas Bueno-de-Mesquita, … show all 50

Purpose
Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan).

Methods
The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case–control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer.

Results
Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84).
The association differed by duration of diabetes; risk was highest for those with a duration of 2–8 years (OR = 1.79, 95 % CI: 1.25, 2.55);
there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52).

Conclusions
These findings provide support for a relationship between diabetes and pancreatic cancer risk.
The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

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Figure 1: Diabetes for 2-8 years

PDF is attached at the bottom of this page

Note: PDFs of this journal were all ‘open access’ in Dec 2012

Yes – diabetes is associated with the pancreas, But,

1. Having diabetes lowers vitamin D levels
2. Many cancers, including pancreatic, increase with lowered vitamin D levels

No mention of vitamin D in the paper

See also Vitamin D Life

• Women with diabetes 60 percent more likely to get Cancer (perhaps low vitamin D) – May 2019
• All items in category Pancreatic Cancer 55 items
• Diseases which are related due to vitamin D deficiency which includes the following
  Diabetes ==> Rheumatoid Arthritis
  Diabetes ==> Vertebral fracture in men only
  Association predicted several months before this paper
     Diabetes ==> Cancer Hypothesis, Nov 2012; Boucher BJ and others
  Hypothesis: Having one vitamin D disease increases the probability of another, especially if it consumes vitamin D