The association of serum 25-hydroxyvitamin D and vertebral fractures in patients with type 2 diabetes.

Endocr J. 2012 Oct 13.
Kim YJ, Park SO, Kim TH, Lee JH, Kim SH.
Division of Endocrinology, Department of Internal Medicine, Kwandong University College of Medicine, Myongji Hospital, Koyang, Korea.

Vitamin D is an important regulator of bone health. Previous studies examining the association between vitamin D deficiency and osteoporotic fractures have reported conflicting results. The relationship between vitamin D status and risk of vertebral fractures in diabetic patients is unknown. The objective of this study was to examine whether low serum 25-hydroxyvitamin D 25(OH)D levels were associated with vertebral fractures in patients with type 2 diabetes mellitus. This cross-sectional study was conducted among 161 postmenopausal women and 180 men with type 2 diabetes. Serum concentrations of 25(OH)D were measured and the presence of vertebral fracture was assessed using lateral plain radiographs of the thoracolumbar spine.

Women had lower 25(OH)D levels than men (31.3 ± 17.7 vs. 41.3 ± 26.5 ng/ml, p<0.001). Vertebral fractures were found in 16% of patients. Men with a serum 25(OH)D concentration greater than 30 ng/ml showed a lower prevalence of vertebral fractures compared to those with 20-29.9 ng/ml or those with less than 20 ng/ml (9.4% vs. 17.9% vs. 27.8%, p for trend=0.036).

However, there was no significant association between vitamin D status and the prevalence of vertebral fractures in women (14.4% vs. 19.2% vs. 26.6%, p for trend=0.111).

After adjusting for multiple confounding factors, men with a serum 25(OH)D concentration of less than 20 ng/ml were associated with an increased risk of vertebral fractures (OR 7.87; 95% CI 1.69-36.71), but not women.

In conclusion, serum 25(OH)D levels below 20 ng/ml w ere associated with an increased vertebral fracture risk in men with type 2 diabetes.
PMID: 23064475

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Final form of the publication, a year later

The association of serum 25-hydroxyvitamin D and vertebral fractures in patients with type 2 diabetes.

Endocr J. 2013;60(2):179-84. Epub 2012 Oct 13.
Kim YJ, Park SO, Kim TH, Lee JH, Kim SH.
Division of Endocrinology, Department of Internal Medicine, Kwandong University College of Medicine, Myongji Hospital, Koyang, Korea.

Vitamin D is an important regulator of bone health. Previous studies examining the association between vitamin D deficiency and osteoporotic fractures have reported conflicting results. The relationship between vitamin D status and risk of vertebral fractures in diabetic patients is unknown. The objective of this study was to examine whether low serum 25-hydroxyvitamin D [25(OH)D] levels were associated with vertebral fractures in patients with type 2 diabetes. This cross-sectional study was conducted among 161 postmenopausal women and 180 men with type 2 diabetes. Serum concentrations of 25(OH)D were measured and the presence of vertebral fracture was assessed using lateral plain radiographs of the thoracolumbar spine. Women had lower 25(OH)D levels than men (31.3 ± 17.7 vs. 41.3 ± 26.5 ng/mL, p<0.001). Vertebral fractures were found in 16% of patients. Men with a serum 25(OH)D concentration greater than 30 ng/mL showed a lower prevalence of vertebral fractures compared to those with 20-29.9 ng/mL or those with less than 20 ng/mL (9.4% vs. 17.9% vs. 21.7%, p for trend=0.036). However, there was no significant association between vitamin D status and the prevalence of vertebral fractures in women (14.4% vs. 19.2% vs. 26.6%, p for trend=0.111). After adjusting for multiple confounding factors, men with a serum 25(OH)D concentration of less than 20 ng/mL were associated with an increased risk of vertebral fractures (OR 7.87; 95% CI 1.69-36.71), but not women. In conclusion, serum 25(OH)D levels below 20 ng/mL were associated with an increased vertebral fracture risk in men with type 2 diabetes.

PMID: 23064475

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See also Vitamin D Life

• Overview Fractures and vitamin D
• All items in category Falls or Fractures and Vitamin D 219 items
• Diseases which become related due to vitamin D deficiency