3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012

Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival.

J Oral Pathol Med. 2012 May 22. doi: 10.1111/j.1600-0714.2012.01164.x.
Zeljic K, Supic G, Stamenkovic Radak M, Jovic N, Kozomara R, Magic Z.
Institute for Medical Research, Military Medical Academy, Belgrade, Serbia Faculty of Biology, University of Belgrade, Belgrade, Serbia Clinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia.

Background: Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in vitamin D metabolism pathway, CYP27B1 and CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma. The purpose of this study was to evaluate the associations between VDR, CYP27B1 and CYP24A1 gene polymorphisms with oral cancer risk and survival.

Methods: Study cohort consisted of 110 patients with oral cancer and 122 healthy controls.
The genotypes of the analysed genes were determined by PCR-RFLP or real-time PCR method.

Results: The significant decrease of oral cancer risk was observed in individuals with heterozygote genotype of CYP24A1 gene (rs2296241) (odds ratio 0.281, P?=?0.000) in comparison with wild type. Patients with VDR FokI ff wild type genotype had significantly worse overall survival (P?=?0.012, log rank) compared with heterozygous and mutated genotype combined. A stratified analysis by the lymph node involvement and tumour stage showed that ff is associated with poor survival in groups with and without lymph node involvement (P?=?0.025, P?=?0.040, respectively) and in stage III tumours (P?=?0.026). Multivariate Cox's regression analysis revealed that VDR FokI could be considered an independent prognostic factor.

Conclusion: Our findings indicate that CYP24A1 gene polymorphism might have an influence on the susceptibility to oral cancer.
VDR FokI polymorphism was associated with worse survival and could be considered as an independent prognostic marker.

© 2012 John Wiley & Sons A/S. PMID: 22612324

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Comment by Vitamin D Life

• These genes have been identified in many many vitamin D and cancer studies.
• It appears that these genes effectively make the body 3X less sensitive to vitamin D.
• The solution may be to just increase the vitamin D levels by 3X

See also Vitamin D Life

• Breast Cancer incidence change by 40 % with vitamin D receptor genes – Oct 2012
  Incidence both increase and decrease
• 35 items in CYP27B1 category
• Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013
• Response to vitamin D depended on Folk-I gene – Nov 2012
• Oral cancer risk and vitamin D status, intake, and supplementation - review May 2013