Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients.
– – – – – – – – – – – – – – – – – –
Context: Many studies have found that blacks may have a lower level of blood levels of vitamin D. Perhaps the actual bioavailable levels are the same in blacks and whites
- Overview Dark Skin and Vitamin D
- All items in category Skin Color and Vitamin D 189 items March 2012
- Genetic differences explain some of vitamin D variation in African-Americans Dec 2011
- 20 ng of vitamin D is enough for African American PTH – Dec 2011
– – – – – – – – – – – – – – – – – – – -
Kidney Int. 2012 Mar 7. Doi: 10.1038/ki.2012.19.
Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI.
Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Prior studies showed conflicting results regarding the association between 25-hydroxyvitamin D (25(OH)D) levels and mineral metabolism in end-stage renal disease. In order to determine whether the bioavailable vitamin D (that fraction not bound to vitamin D-binding protein) associates more strongly with measures of mineral metabolism than total levels, we identified 94 patients with previously measured 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)(2)D) from a cohort of incident hemodialysis patients.
Vitamin D-binding protein was measured from stored serum samples.
Bioavailable 25(OH)D and 1,25(OH)(2)D were determined using previously validated formulae.
Associations with demographic factors and measures of mineral metabolism were examined.
When compared with whites, black patients had lower levels of total, but not bioavailable, 25(OH)D.
Bioavailable, but not total, 25(OH)D and 1,25(OH)(2)D were each significantly correlated with serum calcium.
In univariate and multivariate regression analysis, only bioavailable 25(OH)D was significantly associated with parathyroid hormone levels. Hence, bioavailable vitamin D levels are better correlated with measures of mineral metabolism than total levels in patients on hemodialysis.
Kidney International advance online publication, 7 March 2012; doi:10.1038/ki.2012.19.
PMID: 22398410