__Update: Vitamin D and Omega-3 Ineffective for Preventing Cancer and Heart Disease (too little was used) – Nov 2018_-

DO-HEALTH

• July 2012 to July 2017
• Europe randomized controlled clinical trial (2x2x2 factorial design = 2 levels of vitamin D, two levels of Omega 3, two types of exercise)
• 70+ year old seniors
• 1 page DO-HEALTH summary Feb 2012
• 8 treatment groups with the 3 interventions alone or combined:
• interventional Vitamin D dosage: 2,000 IU versus placebo.
  They anticipate many participants will take 800 IU (standard of care), thus the amount might be as much as 2800 IU down to 800 IU
• Omega 3: 1 g (EPA+DHA) per day versus placebo.
• exercise: two interventional programs focused either on “muscle strength” or “joint mobility”. Both programs performed 3 times/ week for 30 minutes
• calcium supplements will be allowed up to a dose of 500 mg per day max (plus diet intake)
• no indication on Magnesium intake
• Compliance: individual follow-up with study personnel every 3 months by phone call or clinical visit to assess new health-related events, ARs, major lifestyle changes, assess compliance and motivate participants
  Compliance might be enhanced by marking it on the calendar for taking weekly
      1 pill taken about once a week instead of having to remember to take a pill every day.
  no indication of any increase of vitamin D for those who have medications which reduce the vitamin D response
  no indication of giving more vitamin D for those seniors who are obese, have dark skin, or who have medical reasons for having a low response to vitamin D
• no loading dose. Other studies indicate that the benefit of the vitamin D might not even start in the first year. - see references below
• Sponsored by European Commission within the European 7th Framework Program for Research and Technological Development.
  The Universities involved and three industrial sponsors (DSM Nutritional Products, Roche and Nestlé Health Science) are co-funding the study.

Press Release in many languages is attached at bottom of this page

See also Vitamin D Life

• Oveview Seniors and Vitamin D
• All items in Omega-3 330 items
• All items in category Seniors and Vitamin D 341 items
• All items in category Mortality and Vitamin D 207 items
• Overview of Vitamin D Wiki for Fraser Health - Nov 2011
• Long term care – vitamin D most popular supplement – Jan 2012
• Elderly need 2000 to 3000 IU of vitamin D– June 2010
• Vitamin D may help prevent macular degeneration in women younger than 75 – April 2011
• “Sunlight Officers” in some Australian senior facilities – Sept 2011 might be at least as important as exercise
• Half of the seniors needed more than 50,000 IU vitamin D3 monthly – April 2011
• Seniors who increased vitamin D got more physical exercise – Feb 2011
• 65+ years old need 5,000 IU
• 4000 IU Vitamin D intervention helped elderly bones – March 2010
• 2000 IU vitamin D was safe and helped elderly – Feb 2011
• 2000 to 3000 IU required to start to help with osteoporos – June 2010
• 2000 IU barely raised vitamin D levels after hip fracture - May 2010 file
• Seniors needed 2000 to 3000 IU of vitamin D to increase serum levels – June 2010
• 20 year review concludes that Vitamin D reduce aging – July 2010
• Dietary Guidelines vitamin D - virtually no senior gets enough - June 2010 great graph
• 300,000 IU vitamin D helped seniors in many ways – May 2011
• All items in category MegaDose Vitamin D
• Vitamin D3 loading dose of 500,000 IU for elderly – Aug 2009
• Loading vitamin D which has the following table

140,000 IU	10 ng	200 lb
70,000 IU	20 ng	200 lb
105,000 IU	10 ng	150 lb

• Fraser Health giving 20,000 IU vitamin D weekly to reduce falls – Nov 2011 see following graph

See also web

• VITAL Clinical Trial add Omega 3 and 2000 IU of vitamin D
  Estimated completion June 2016, Run by Dr. Manson who served on IoM committee which recommended just 600 IU of vitamin D
  Why we need large-scale heart trials of vitamin D - Dec 2010 in Vitamin D Life