Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer.

Cancer Epidemiol Biomarkers Prev. 2011 Nov 15.
Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, Ma J, Buring JE, Sesso H, Lee IM, Rifai N, Cochrane BB, Wactawaski-Wende J, Chlebowski RT, Willett WC, Manson JE, Giovannucci EL, Fuchs CS.
1 Dept of Medical Oncology, Dana-Farber Cancer Institute.

BACKGROUND:
Laboratory studies suggest vitamin D may inhibit pancreatic cancer cell growth.
However, epidemiologic studies of vitamin D and pancreatic cancer risk have been conflicting.

METHODS:
To determine whether prediagnostic levels of plasma 25-hydroxyvitamin D (25[OH]D) were associated with risk of pancreatic cancer, we performed a nested case-control study of 451 cases and 1167 controls from five cohorts through 2008.
Logistic regression was used to compare the odds of pancreatic cancer by plasma level of 25(OH)D.

RESULTS:
Mean plasma 25(OH)D was lower in cases versus controls (61.3 vs. 64.5 nmol/L, P=0.005).
In logistic regression models, plasma 25(OH)D was inversely associated with odds of pancreatic cancer.
Participants in quintiles two through five had multivariable-adjusted odds ratios (OR [95% confidence intervals]) of

• 0.79 (0.56-1.10),
• 0.75 (0.53-1.06),
• 0.68 (0.48-0.97), and
• 0.67 (0.46-0.97); P-trend=0.03), respectively, compared to the bottom quintile.

Compared to those with insufficient levels (25[OH]D<50 nmol/L), ORs were

• 0.75 (0.58-0.98) for subjects with relative insufficiency (25[OH]D 50-<75 nmol/L) and
• 0.71 (0.52-0.97) for those with sufficient levels (25[OH]D?75 nmol/L).

No increased risk was noted in subjects with 25(OH)D ?100 nmol/L, as suggested in a prior study.
In subgroup analyses, ORs for the top versus bottom quartile of 25(OH)D were

• 0.72 (0.48-1.08) for women,
• 0.73 (0.40-1.31) for men, and
• 0.73 (0.51-1.03) for Whites.

CONCLUSIONS:
Among participants in five large prospective cohorts, higher plasma levels of 25(OH)D were associated with a lower risk for pancreatic cancer.
Impact: Low circulating 25(OH)D may predispose individuals to the development of pancreatic cancer.
PMID: 22086883
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30% less likely to get Pancreatic Cancer if >30 nanograms vs those with < 20 nanograms

See also Vitamin D Life

• All items in category Pancreatic Cancer 55 items
• Vitamin D and Pancreatic Cancer - Sept 2010.PDF file
• Overview all Cancers and vitamin D
• Pancreatic Cancer association with PRKCA gene and the active form of vitamin D – Nov 2012
• Far fewer Pancreatic Cancer deaths at stage III and IV with more than 20 ng vitamin D – Sept 2013

See also web

• Vitamin D Council on Pancreatic Cancer
• How Vitamin K (1, 2, or 5) combined with Sorafenib treats Pancreatic Cancer perhaps 20X better than either item by itself
  Journal Cell Physiology, 2010, full text on-line