(WO2010075537) FORMULATIONS COMPRISING VITAMIN D OR DERIVATIVES THEREOF
Clipped from patent
“However, cholecalciferol is seen to be very unstable and is especially unstable in the presence of oxygen. It has therefore been difficult to provide formulations of cholecalciferol which are stable. This lack of stability may often be detected as a drop in the level of cholecalciferol in a formulation measured using a cholecalciferol assay.”
“The present invention provides a stable pharmaceutical delivery system comprising vitamin D or derivatives thereof, preferably cholecalciferol. In a first aspect, the present invention provides a pharmaceutical delivery system comprising: i) an inert core, ii) an inner layer comprising vitamin D or a derivative thereof, preferably cholecalciferol, an emulsifier and an anti-oxidant, and iii) an outer protective layer.”
Owner of patent = TEVA PHARMACEUTICAL INDUSTRIES, US
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Wonder if oxidation is a portion of the reason that vitamin D does not appear to be very bio-available in a solid multi-vitamin