Vitamin D and benign gynaecological diseases: A critical analysis of the current evidence.
Gynecol Endocrinol. 2015 Oct 22:1-22. [Epub ahead of print]
Buggio L1, Roncella E1, Somigliana E1, Vercellini P1.
1a Istituto Ostetrico e Ginecologico 'Luigi Mangiagalli', Department of Clinical Science and Community Health, Università degli Studi, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico , Via Commenda , 12 - 20122 Milano , Italy .
Vitamin D is a fat-soluble pro-hormone that plays an important role in bone homeostasis; beside this principal function, vitamin D promotes modulation of cell growth, neuromuscular and immune function, and reduction of inflammation. In addition, several in vitro and in vivo studies have demonstrated that vitamin D deficiency could increase the risk of cancer, autoimmune and cardiovascular diseases. Moreover, vitamin D plays also an important role in female reproduction, due to the fact that vitamin D receptors are expressed in ovarian tissue, endometrium, fallopian epithelial cells as well as in decidua and placenta. We aimed to review the most updated evidence, which suggests a link between vitamin D metabolism and the development of some gynaecological diseases, such as
- endometriosis,
- uterine fibroids, and
- polycystic ovary syndrome.
PMID: 26490176
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