Recurrent urinary tract infection 4X more likely if low vitamin D – Aug 2013

The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women.

Int J Infect Dis. 2013 Aug 1. pii: S1201-9712(13)00219-1. doi: 10.1016/j.ijid.2013.06.007.
Nseir W, Taha M, Nemarny H, Mograbi J.
Department of Internal Medicine, EMMS Nazareth, The Nazareth Hospital, Nazareth, Israel; Infectious Diseases Unit, EMMS Nazareth, The Nazareth Hospital, Nazareth, Israel; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel. Electronic address: w.nseir at yahoo.com.

OBJECTIVES: To examine whether there is any association between serum levels of 25-hydroxy vitamin D (25(OH) vitamin D) and the recurrence of urinary tract infections (UTIs) among premenopausal women.

METHODS: During a period of 3 years, 93 premenopausal women with a medical history of recurrent UTIs were enrolled from the Infectious Diseases Unit. Cases with recurrent UTIs were compared to 93 age-matched (±5 years) women with no history of recurrent UTI (control group), in terms of serum 25(OH) vitamin D and different risk factors for recurrent UTI. Recurrent UTI was defined as three or more episodes of UTI over a 12-month period.

RESULTS: The mean age of women with recurrent UTIs was 43.8±9 years and of controls was 39±10 years (p=0.839). The mean serum levels of 25(OH) vitamin D among women with recurrent UTIs were significantly lower than those of controls (9.8 ng/ml ± 4 vs. 23 ng/ml ± 6; p<0.001). Multivariate analysis showed that a serum 25(OH) vitamin D level of <15 ng/ml (odds ratio 4.00, 95% confidence interval 3.40-4.62; p=0.001) was associated with recurrent UTIs in premenopausal women.

CONCLUSIONS: In this retrospective study, we found that recurrent UTIs in premenopausal women are associated with vitamin D deficiency.

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See also web

• D-Mannos Decreases Risk of Urinary Tract Infections Swanson Research, Sept 2013     Abstract
  Women with recurrent UT:I with placebo = 60% in 6 months,
  UTI with Nitrofurantoin = 20% in 6 months
  UTI with 2 grams/day of D-Mannose = 14% in 6 months (better than the commercial drug)
     UTI in placebo group was 4X more frequent than D-Mannose,which is the same ratio as the Vitamin D study on this page
        Wonder what the UTI decrease would be if a woman took BOTH Vitamin D AND D-Mannose?
         Google Search UTI ("Vitamin D" AND D-Mannose) 66,000 items Sept 2013
• Novel Strategies in the Prevention and Treatment of Urinary Tract Infections - Jan 2016
   Download the PDF from Vitamin D Life