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Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019

Cross-sectional evaluation of the relationship between vitamin D status and supplement use across levels of kidney function in adults.

BMJ Open. 2019 Feb 22;9(2):e022471. doi: 10.1136/bmjopen-2018-022471.
Moore LW1,2, Suki WN3, Lunsford KE1,4, Sabek OM1,4, Knight RJ1,4, Gaber AO1,4.

Vitamin D Life

Items in both Kidney and Calcitriol categories in Vitamin D Life:


Kidney category starts with

Kidney category listing has 193 items

see also Overview Kidney and vitamin D
Search Vitamin D Life for dialysis OR haemodialysis 878 items not in PDF as of Aug 2020
Search Vitamin D Life for kidney transplant 798 items as of June 2019
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 46 items along with related searches

Kidney Intervention trials using Vitamin D:


Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 193 items

Getting Vitamin D into your body

Different forms are needed for different problenms
http://vitad.org/tiki-index.php?page_id=5644

 Download the PDF from Vitamin D Life

OBJECTIVES:
The objective of this study was to assess vitamin D status of US non-pregnant adults using a standardised assay across 15 mL/min/1.73 m2 increments of kidney function, report the use of dietary supplements containing vitamin D and assess relationships between vitamin D and markers of bone resorption.

DESIGN: This study is a cross-sectional evaluation.

SETTING: The study is from the US National Health and Nutrition Evaluation Survey in 2001-2012.

PARTICIPANTS: The participants were non-institutionalised, non-pregnant adults, age ≥20 years.

PRIMARY AND SECONDARY OUTCOME MEASURES:
The primary outcome measure was serum 25OHD evaluated using liquid chromatography-tandem mass spectroscopy traceable to international reference standards. Secondary outcome measures were use of dietary supplements containing vitamin D and the serum intact parathyroid hormone and bone-specific alkaline phosphatase in a subset of participants.

RESULTS:
The median 25OHD concentration in 27 543 US non-pregnant adults was 25.7 ng/mL (range, 2.2-150.0 ng/mL). Vitamin D supplements were used by 38.0%; mean (SE)=757 (43) international units/day. The range of 25OHD concentration across groups, stratified by kidney function, was 23.0-28.1 ng/mL. The lowest concentration of 25OHD observed was in people with higher kidney function (23.0 ng/mL for estimated glomerular filtration rate >105 mL/min/1.73 m2). Only 24% of people not taking a dietary supplement had a 25OHD concentration >30 ng/mL. Serum intact parathyroid hormone inversely correlated with 25OHD within all kidney function groups. Bone-specific alkaline phosphatase was also negatively associated with 25OHD concentration.

CONCLUSIONS:
These data indicate that 25OHD concentrations and supplement use may be suboptimal in a significant proportion of the population, across all kidney function levels. The response of bone resorption markers further suggests that 25OHD levels could be improved. Together, these data support a re-evaluation of the 25OHD concentration associated with health in adults.


Created by admin. Last Modification: Monday September 30, 2019 02:39:45 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11463 Kidney cross-section.pdf PDF 2019 admin 25 Feb, 2019 15:10 513.48 Kb 216
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