Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms.
Nutrition. 2019 Feb 19;63-64:148-154. doi: 10.1016/j.nut.2019.02.003.
Al-Daghri NM1, Mohammed AK2, Bukhari I3, Rikli M4, Abdi S5, Ansari MGA5, Sabico S5, Hussain SD5, Alenad A6, Al-Saleh Y4, Alokail MS6.
Poor response = < 20 ng after 8 weeks of 50,000 IU Vitmin D weekly
Poor response due to poor VDRP has been documented in many studies
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Response to Vitamin D varies with Vitamin D Binding Protein gene – RCT May 2018
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
Vitamin D Binding Protein category listing has 141 items has the followingVitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Genetics category listing contains the following
266 articles in the Genetics category see also
384 articles in Vitamin D Receptor141 articles in Vitamin D Binding Protein = GC35 articles in CYP27B1- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
See also web
- Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions - May 2019 doi: 10.3389/fendo.2019.00317 Free PDF
Download the PDF from Vitamin D Life
RS4588
OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.
METHODS: In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D <50 nmol/L] were given 50 000 IU of vitamin D supplements for 8 wk followed by daily maintenance of 1000 IU for 4 mo. Two single-nucleotide polymorphisms (rs4588 and rs7041) in DBP coding gene were assessed.
RESULTS: Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Post supplementation 25(OH)D was significantly higher in participants with homozygous major genotypes of either rs4588 and rs7041 than other genotypes (P < 0.001).
Participants with the minor allele of either rs4588 or rs7041 were 2.9 (1.9-4.5) times and 3.7 (2.1-6.6) times, respectively, more likely to be non-responders (post supplementation 25 OHD <50 nmol/L) than those homozygous for the major allele at these locations (P < 0.001).
Furthermore, participants with homozygous minor and heterozygous genotype of rs7041 were 6.2 and 4.2 times more likely to be non-responders than those with the homozygous major genotype (P < 0.001) even after adjustments for age, sex, body mass index, baseline 25(OH)D concentration, and other alleles.
Participants with homozygous minor and heterozygous genotypes of rs4588 were 4.1 and 12.4 times more likely to be non-responders than those with homozygous major genotypes. These significant risks, however, were lost after adjustment.
CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.
Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019 892 visitors, last modified 15 Jun, 2019,
Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category) Top news 816 Vit D Binding Protein 141 Attached files
ID Name Comment Uploaded Size Downloads 11733 T5 VDBP.jpg admin 09 Apr, 2019 14:06 54.57 Kb 205 11731 non-responders.jpg admin 09 Apr, 2019 12:52 12.01 Kb 181 11730 vitamin D-binding protein polymorphisms.pdf PDF 2019 admin 09 Apr, 2019 12:27 550.15 Kb 208
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Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Genetics category listing contains the following
see also
384 articles in Vitamin D Receptor 141 articles in Vitamin D Binding Protein = GC 35 articles in CYP27B1 - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
See also web
- Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions - May 2019 doi: 10.3389/fendo.2019.00317 Free PDF
Download the PDF from Vitamin D Life
RS4588
OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.
METHODS: In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D <50 nmol/L] were given 50 000 IU of vitamin D supplements for 8 wk followed by daily maintenance of 1000 IU for 4 mo. Two single-nucleotide polymorphisms (rs4588 and rs7041) in DBP coding gene were assessed.
RESULTS: Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Post supplementation 25(OH)D was significantly higher in participants with homozygous major genotypes of either rs4588 and rs7041 than other genotypes (P < 0.001).
Participants with the minor allele of either rs4588 or rs7041 were 2.9 (1.9-4.5) times and 3.7 (2.1-6.6) times, respectively, more likely to be non-responders (post supplementation 25 OHD <50 nmol/L) than those homozygous for the major allele at these locations (P < 0.001).Furthermore, participants with homozygous minor and heterozygous genotype of rs7041 were 6.2 and 4.2 times more likely to be non-responders than those with the homozygous major genotype (P < 0.001) even after adjustments for age, sex, body mass index, baseline 25(OH)D concentration, and other alleles.
Participants with homozygous minor and heterozygous genotypes of rs4588 were 4.1 and 12.4 times more likely to be non-responders than those with homozygous major genotypes. These significant risks, however, were lost after adjustment.CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.
Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019Printer Friendly PDF this page! Follow this page for updates892 visitors, last modified 15 Jun, 2019, This page is in the following categories (# of items in each category)Top news816 Vit D Binding Protein 141 Attached files
ID Name Comment Uploaded Size Downloads 11733 T5 VDBP.jpg admin 09 Apr, 2019 14:06 54.57 Kb 205 11731 non-responders.jpg admin 09 Apr, 2019 12:52 12.01 Kb 181 11730 vitamin D-binding protein polymorphisms.pdf PDF 2019 admin 09 Apr, 2019 12:27 550.15 Kb 208 See any problem with this page? Report it (FINALLY WORKS)