Off-topic: Sulfur is very important to health

Comment by Henry Lahore of Vitamin D Life

• Organic sulfur has been proven by many studies to help human health
• Non-organic sulfur appears to help as well - I am unaware of as many studies

Off topic: Sulfur and Human Health - many items 2011-2013

Note: Search Pubmed for Sulfroaphone 1131 items in title as of April 2020
Sulforaphane treatment of autism spectrum disorder - RCT 2014
   Very small trial using a type of Sulforaphane only available by prescription. Great results
    Download the PDF from Vitamin D Life

See also web

• Sulforaphane Examine.com as of Dec 2016: with 91 references
  • "Sulforaphane is an anti-cancer compound in cruciferous vegetables, mostly commonly credited to Broccoli.
    It appears to have general but potent antioxidant and possible anti-inflammatory actions, with the former similar to Curcumin."
  • ""Sulforaphane may release hydrogen sulfide in the body following oral ingestion, suggesting that many of its mechanisms would parallel that of garlic or SAMe (another H2S releasing supplement)""
  • half-life of only 2 hours
• 270 Abstracts with Sulforaphane Research GreenMedInfo Dec 2016
• Amazingly, suforaphane has been shown to increase expression of the VDR gene!
  No date, not say how much of an increase, no references
• Synergistic Mediation of Sulforaphane and Vitamin D on the Wnt-signaling Pathway Jan 2017
  •  Download the technical PDF from Vitamin D Life

Sulforaphane – Organic Sulfur – video Dec 2016

Dr. Rhonda Patrick ( FoundMyFitness) posted
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More

The time has come for me to finally release my video on sulforaphane. You guys got a little bit of an audio-only preview a while back, but this has been revised: we made some corrections and then also added citations, figures, graphs, quotations from the studies, etc. for pretty much absolutely everything discussed.

Here's the bottom-line of why I'm so excited about this video:
sulforaphane is probably one of the most important health-promoting compounds in existence.

I believe if, as a world population, everyone started increasing their intake of isothiocyanates just a little bit, we'd see a complete shift in the disease curve worldwide. The research is that promising.

WATCH THE SULFORAPHANE VIDEO NOW YouTube
(Note: YouTube settings allows speed change: 1.0, 0.5, 1.25, and 1.5 - which I use)

My goal with this video was to distill down the most interesting parts of a huge body of literature into an coherent narrative that people can follow. I think I've mostly achieved that... but I was so excited about this topic that I decided to reach out to a name I was seeing show up on the studies I was reading time and time again: Dr. Jed Fahey of Johns Hopkins. We ended up recording a 2 hour interview of completely non-overlapping material that is actually very complimentary and also covers surprisingly practical information! He's been one of the driving forces ultimately moving this field forward... his lab has also played a critical role in providing the "infrastructure" (e.g. broccoli sprout extracts) to labs looking to do this type of research. Expect to see that conversation very soon as a follow-up!

Okay, but enough about upcoming videos... here's the low-down on what's in THIS video. Just a few of the effects talked about in the video that are related primarily to supplementation of sulforaphane (or broccoli sprouts or other isothiocyanate-rich foods)...

• Profound changes in lipid biomarkers, reducing heart disease risk by as much as 50% in humans.
• Massive reductions in cancer risk in humans and also highly effective as a cancer intervention, particularly prostate and breast but also many others.
• Steep reductions in inflammation in humans.
• Possible implications for neurodegenerative disorders and traumatic brain injury.
• Shown in mice to be as effective as Prozac as an anti-depressant.
• Steep behavioral changes in humans with respect to certain neurological disorders, such as autism.
• Causes dramatic boosts in the excretion of certain air pollutants and cigarette carcinogens (up to 60%) in humans.

In some ways, however, to try to distill this video down to just a few bulletpoints of effects really does feel like it diminishes the value of these compounds a bit... so I hope you watch the whole thing! Please do that. Then share it with a friend.

I've created a timeline, which I'll attach to the bottom of this message, to help you skip around a little bit and also give you a sense of what's actually in the video too. This is also attached to the YouTube video's description.

That's it for now... as a closing thought: THANK YOU SO MUCH FOR BEING A PART OF THIS! I could NOT have done this without you guys. It took too much time that I wouldn't have otherwise been able to invest. Ultimately, it took more time than what is clearly part of the stated goals for my channel (in terms of frequency)... but, without your support, I couldn't have taken on a big piece like this and I knew that it was a story that deserved to be told. It was too important and there was too much literature to cover and to try to break it into smaller pieces would've left the viewer without a sense of the momentousness of what was being discussed.

Thank you for letting me do this!
Rhonda
Full timeline:

• 00:34 - Introduction of sulforaphane, a major focus of the video.
• 01:14 - Cruciferous vegetable consumption and reductions in all-cause mortality.
• 02:12 - Prostate cancer risk.
• 02:23 - Bladder cancer risk.
• 02:34 - Lung cancer in smokers risk.
• 02:48 - Breast cancer risk.
• 03:13 - Hypothetical: what if you already have cancer? (interventional)
• 03:35 - Plausible mechanism driving the cancer and mortality associative data.
• 04:38 - Sulforaphane and cancer.
• 05:32 - Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
• 06:06 - Effect of direct supplementation of sulforaphane in prostate cancer patients.
• 07:09 - Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
• 08:32 - Inhibition of breast cancer stem cells.
• 08:53 - History lesson: brassicas were established as having health properties even in ancient Rome.
• 09:16 - Sulforaphane's ability to enhance carcinogen excretion (benzene, acrolein).
• 09:51 - NRF2 as a genetic switch via antioxidant response elements.
• 10:10 - How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
• 10:34 - Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
• 11:20 - Broccoli sprout drink increases benzene excretion by 61%.
• 13:31 - Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
• 15:45 - Cruciferous vegetable consumption and heart disease mortality.
• 16:55 - Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
• 19:04 - Beginning of aging section.
• 19:21 - Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
• 20:34 - Importance of low inflammation for longevity.
• 22:05 - Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
• 23:40 - Mid-video recap: cancer, aging sections
• 24:14 - Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
• 25:18 - Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
• 26:30 - Beginning of brain and behavior section.
• 27:18 - Effect of broccoli sprout extract on autism.
• 27:48 - Effect of glucoraphanin on schizophrenia.
• 28:17 - Start of depression discussion (plausible mechanism and studies).
• 31:21 - Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
• 32:00 - Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
• 33:01 - Beginning of neurodegeneration section.
• 33:30 - Sulforaphane and Alzheimer's disease.
• 33:44 - Sulforaphane and Parkinson's disease.
• 33:51 - Sulforaphane and Hungtington's disease.
• 34:13 - Sulforaphane increases heat shock proteins.
• 34:43 - Beginning of traumatic brain injury section.
• 35:01 - Sulforaphane injected immediately after TBI improves memory (mouse study).
• 35:55 - Sulforaphane and neuronal plasticity.
• 36:32 - Sulforaphane improves learning in model of type II diabetes in mice.
• 37:19 - Sulforaphane and duchenne muscular dystrophy.
• 37:44 - Myostatin inhibition in muscle satellite cells (in vitro).
• 38:06 - Late-video recap: mortality and cancer, DNA damage, oxidative stress and
      inflammation, benzene excretion, cardiovascular disease, type II diabetes,
      effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
• 40:27 - Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
• 41:01 - Anecdotes on sprouting at home.
• 43:14 - On cooking temperatures and sulforaphane activity.
• 43:45 - Gut bacteria conversion of sulforaphane from glucoraphanin.
• 44:24 - Supplements work better when combined with active myrosinase from vegetables.
• 44:56 - Cooking techniques and cruciferous vegetables.
• 46:06 - Isothiocyanates as goitrogens.