Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.
Levine ME1, Suarez JA2, Brandhorst S2, Balasubramanian P2, Cheng CW2, Madia F3, Fontana L4, Mirisola MG5, Guevara-Aguirre J6, Wan J2, Passarino G7, Kennedy BK8, Wei M2, Cohen P2, Crimmins EM1, Longo VD9.
Note: This study does not seem to discuss meat with/without antibiotics, roundup, etc.
Dr. Greger short videos with transcripts
Dialing Down the Grim Reaper Gene July 2019
- "But did you notice that it says not among older individuals? All of this is covered in my video Increasing Protein Intake After Age 65."
- "But if you look at the actual study, you’ll see that’s simply not true. Those eating lots of animal protein didn’t have four times more risk of dying from diabetes; they had 73 times the risk"
Animal Protein Compared to Cigarette Smoking Aug 2016
Sources
- M E Levine, J A Suarez, S Brandhorst, P Balasubramanian, C W Cheng, F Madia, L Fontana, M G Mirisola, J Guevara-Aguirre, J Wan, G Passarino, B K Kennedy, M Wei, P Cohen, E M Crimmins, V D Longo.Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 4;19(3):407-17.
- R Steuerman, O Shevah, Z Laron. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. Eur J Endocrinol. 2011 Apr;164(4):485-9.
- T T Fung, R M van Dam, S E Hankinson, M Stampfer, W C Willett, F B Hu. Low-carbohydrate diets and all-cause and cause-specific mortality: two cohort studies. Ann Intern Med. 2010 Sep 7;153(5):289-98.
- H Noto, A Goto, T Tsujimoto, M Noda. Low-carbohydrate diets and all-cause mortality: a systematic review and meta-analysis of observational studies. PLoS One. 2013;8(1):e55030.
- S Wu. Meat And Cheese May Be as Bad for You as Smoking. Released by University of Southern California, Published: March 4, 2014.
- J Guevara-Aguirre, P Balasubramanian, M Guevara-Aguirre, M Wei, F Madia, C W Cheng, D Hwang, A Martin-Montalvo, J Saavedra, S Ingles, R de Cabo, P Cohen, V D Longo. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16;3(70):70ra13.
- C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang. A C. elegans mutant that lives twice as long as wild type. Nature. 1993 Dec 2;366(6454):461-4.
- I Sample. Diets high in meat, eggs and dairy could be as harmful to health as smoking.
- L Partridge, P H Harvey. Gerontology. Methuselah among nematodes. Nature. 1993 Dec 2;366(6454):404-5.
- Y Suh, G Atzmon, M O Cho, D Hwang, B Liu, D J Leahy, N Barzilai, P Cohen. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3438-42.
- T T Perls, K Bochen, M Freeman, L Alpert, M H Silver. Validity of reported age and centenarian prevalence in New England. Age Ageing. 1999 Mar;28(2):193-7.
- N E Allen, P N Appleby, G K Davey, R Kaaks, S Rinaldi, T J Key. The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1441-8.
- P Coffer. OutFOXing the grim reaper: novel mechanisms regulating longevity by forkhead transcription factors. Sci STKE. 2003 Sep 23;2003(201):PE39.
- H J Jung, Y Suh. Regulation of IGF -1 signaling by microRNAs. Front Genet. 2015 Jan 13;5:472.
- T H Ngo, R J Barnard, C N Tymchuk, P Cohen, W J Aronson. Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control. 2002 Dec;13(10):929-35.
- R J Barnard, J H Gonzalez, M E Liva, T H, Ngo. Effects of a low-fat, high-fiber diet and exercise program on breast cancer risk factors in vivo and tumor cell growth and apoptosis in vitro. Nutr Cancer. 2006;55(1):28-34.
- TJ Key, PN Appleby, EA Spences, RC Travis, AW Roddam, NE Allen. Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). Am J Clin Nutr 2009 May;89(5):1620S-6S.
- D Ornish, G Weidner, W R Fair, R Marlin, E B Pettengill, C J Raisin, S Dunn-Emke, L Crutchfield, F N Jacobs, R J Barnard, W J Aronson, P McCormac, D J McKnight, J D Fein, A M Dnistrian, J Weinstein, T H Ngo, N R Mendell, P R Carroll. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. 2005 Sep;174(3):1065-9; discussion 1
Download the PDF from Vitamin D Life
Mice
Mice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50-65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.