Association of the vitamin D metabolism gene GC and CYP27B1 polymorphisms with cancer susceptibility: a meta-analysis and trial sequential analysis
Bioscience Reports Aug 29, 2019 DOI: 10.1042/BSR20190368
Man Zhu, Zheqiong Tan, Zhenzhao Luo, Hui Hu, Tangwei Wu, Shiqiang Fang, Hui Wang, Zhongxin LuB
35 items in CYP27B1 categoryGenetics category listing contains the following
266 articles in the Genetics category see also
384 articles in Vitamin D Receptor141 articles in Vitamin D Binding Protein = GC35 articles in CYP27B1- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
Vitamin D Binding Protein category listing has 141 items and the following introduction__Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Items in both categories Vitamin D Binding Protein and Breast Cancer are listed here:
Items in both categories Vitamin D Binding Protein and Other Cancer are listed here:
- 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020
- Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study) – Oct 2019
- Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019
- 5X less risk of Kidney cancer if good ratio of Vitamin D binding protein to circulating vitamin D – Nov 2013
Note: This study did not investigate many other genes which also restrict D from getting to the cells
Additional information on Genes in Vitamin D Life
Gene # of pages Location CYP27A1 449 (Sept 2019) Liver CYP2R1 826 (Sept 2019) Liver & Tissue CYP27B1 1430 (Sept 2019) Kidney & Tissue CYP24A1 1360 (Sept 2020) excrete excess
- Vitamins regulate some human genes – Feb 2020
- The genetics of vitamin D – Oct 2018
- Does survival of the less fit mean less health genes getting worse over generations
- More genes changed with higher doses of Vitamin D (suggest future gene studies) - RCT Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
Download the PDF from Vitamin D Life
Nowadays, vitamin D is known to have functions beyond bone formation, including inhibiting angiogenesis and promoting tumor apoptosis. CYP27B1 and group-specific component (GC), the main enzyme responsible for the degradation and transport of active vitamin D, play important role in many cancer related cellular processes. Relationships between CYP27B1 and GC polymorphisms and cancer susceptibility have been widely investigated, whereas the results are inconsistent. We strictly searched on EMBASE, PubMed, Web of Science, Wan Fang and CNKI electronic databases for relevant studies exploring the associations of GC (rs4588 and rs7041) and CYP27B1 (rs4646537, rs3782130) polymorphisms with cancer risks according to search strategy. Thirty-two studies published in thirteen articles involving 15,713 cases and 17,304 controls were included.
Our analyses suggested that rs4588 and rs7041 polymorphisms were significantly associated with overall cancer risk. Stratification analyses of ethnicity indicated that rs4588 polymorphism significantly increased cancer risk in Caucasians and Asians, while rs7041 polymorphism significantly increased cancer risk in Asians. When studies were stratified by cancer type, our results indicated that rs4588 significantly increased the risk of breast cancer and digestive system tumor, but not in prostate cancer and non-small cell lung cancer, while rs7041 significantly increased the risk of non-small cell lung cancer. Above associations were noteworthy findings as evaluated by false-positive report probabilities (FPRP). There were no associations of rs4646537 and rs3782130 with overall cancer risks. Associations between CYP27B1 and GC polymorphisms and cancer risks were examined, and additional large samples are necessary to validate our results.
Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019 723 visitors, last modified 07 Oct, 2019,
Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category)
Genetics category listing contains the following
see also
384 articles in Vitamin D Receptor 141 articles in Vitamin D Binding Protein = GC 35 articles in CYP27B1 - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
Vitamin D Binding Protein category listing has
141 items and the following introduction__ Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Items in both categories Vitamin D Binding Protein and Breast Cancer are listed here:
Items in both categories Vitamin D Binding Protein and Other Cancer are listed here:
- 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020
- Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study) – Oct 2019
- Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019
- 5X less risk of Kidney cancer if good ratio of Vitamin D binding protein to circulating vitamin D – Nov 2013
Note: This study did not investigate many other genes which also restrict D from getting to the cells
Additional information on Genes in Vitamin D Life
Gene # of pages Location CYP27A1 449 (Sept 2019) Liver CYP2R1 826 (Sept 2019) Liver & Tissue CYP27B1 1430 (Sept 2019) Kidney & Tissue CYP24A1 1360 (Sept 2020) excrete excess - Vitamins regulate some human genes – Feb 2020
- The genetics of vitamin D – Oct 2018
- Does survival of the less fit mean less health genes getting worse over generations
- More genes changed with higher doses of Vitamin D (suggest future gene studies) - RCT Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
Download the PDF from Vitamin D Life
Nowadays, vitamin D is known to have functions beyond bone formation, including inhibiting angiogenesis and promoting tumor apoptosis. CYP27B1 and group-specific component (GC), the main enzyme responsible for the degradation and transport of active vitamin D, play important role in many cancer related cellular processes. Relationships between CYP27B1 and GC polymorphisms and cancer susceptibility have been widely investigated, whereas the results are inconsistent. We strictly searched on EMBASE, PubMed, Web of Science, Wan Fang and CNKI electronic databases for relevant studies exploring the associations of GC (rs4588 and rs7041) and CYP27B1 (rs4646537, rs3782130) polymorphisms with cancer risks according to search strategy. Thirty-two studies published in thirteen articles involving 15,713 cases and 17,304 controls were included.
Our analyses suggested that rs4588 and rs7041 polymorphisms were significantly associated with overall cancer risk. Stratification analyses of ethnicity indicated that rs4588 polymorphism significantly increased cancer risk in Caucasians and Asians, while rs7041 polymorphism significantly increased cancer risk in Asians. When studies were stratified by cancer type, our results indicated that rs4588 significantly increased the risk of breast cancer and digestive system tumor, but not in prostate cancer and non-small cell lung cancer, while rs7041 significantly increased the risk of non-small cell lung cancer. Above associations were noteworthy findings as evaluated by false-positive report probabilities (FPRP). There were no associations of rs4646537 and rs3782130 with overall cancer risks. Associations between CYP27B1 and GC polymorphisms and cancer risks were examined, and additional large samples are necessary to validate our results.Increased risk of various cancers if poor vitamin D genes (Binding Protein and CYP27B1) - Sept 2019Printer Friendly PDF this page! Follow this page for updates723 visitors, last modified 07 Oct, 2019, This page is in the following categories (# of items in each category)