Vitamin D-Binding Protein in Pregnancy and Reproductive Health
by Melinda Fernando 1,Stacey J. Ellery 2OrcID,Clara Marquina 1OrcID,Siew Lim 1,Negar Naderpoor 1,† andAya Mousa 1, aya.mousa at monash.edu,†OrcID
- 1 Monash Centre for Health Research and Implementation (MCHRI) and Centre of Cardiovascular Research and Education in Therapeutics (CCRET), School of Public Health and Preventive Medicine, Monash University, Melbourne 3168 VIC, Australia
- 2 The Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynaecology, Monash University, Melbourne 3168 VIC, Australia
Pages listed in BOTH the categories Pregnancy and Vitamin D Binding Protein
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
Vitamin D Binding Protein category listing has 141 items and the following introductionVitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Note: Topical Vitamin D does not appear to be blocked by VDBP
Vitamin D Binding Protein has a list of health problems
Increased
Risk Health Problem 11 X Preeclampsia 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2 X MS 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility
Pregnancy category starts with
750 items in Pregnancy category - see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:
Dark Skin 25 ; Depression 17 ; Diabetes 39 ; Obesity 12 ; Hypertension 35 ; Breathing 29 ; Omega-3 30 ; Vitamin D Receptor 18 - All items in category Infant/Child
606 items- breastfed 887 items as of Jan 2018
- Preeclampsia 825 items as of Jan 2018
- Pre-term 4710 items as of Dec 2018
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items as of Aug 2020
- postpartum depression 208 items as of Aug 2018
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 794 as of Feb 2020
- Search Vitamin D Life for "Assisted reproduction" 33 items as of Feb 2017
- Fertility and Sperm category listing has
109 items along with related searches- (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Download the PDF from Vitamin D Life
Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Overall, low levels of maternal serum VDBP concentrations have been associated with infertility, endometriosis, PCOS and spontaneous miscarriage, as well as adverse pregnancy outcomes including GDM, pre-eclampsia, preterm birth and fetal growth restriction. However, increased VDBP concentration in cervicovaginal fluid has been linked to unexplained recurrent pregnancy loss and premature rupture of membranes. Some genetic variants of VDBP have also been associated with these adverse outcomes. Further studies using more accurate VDBP assays and accounting for ethnic variation and potential confounders are needed to clarify whether VDBP is associated with reproductive health and pregnancy outcomes, and the mechanisms underlying these relationships
During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020 347 visitors, last modified 20 May, 2020,
Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category) Pregnancy 750 Vit D Binding Protein 141 Attached files
ID Name Comment Uploaded Size Downloads 13827 VDBPTable B.jpg admin 20 May, 2020 13:50 213.16 Kb 74 13826 VDBPTable A.jpg admin 20 May, 2020 13:47 723.46 Kb 72 13825 VDBP F1.jpg admin 20 May, 2020 13:25 27.87 Kb 96 13824 Vitamin D-Binding Protein in Pregnancy.pdf PDF 2020 admin 20 May, 2020 13:25 536.17 Kb 72
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Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Note: Topical Vitamin D does not appear to be blocked by VDBP
Vitamin D Binding Protein has a list of health problems
| Increased Risk | Health Problem |
| 11 X | Preeclampsia |
| 6 X | Food Allergy |
| 5 X | PTSD |
| 4 X, 5X | Kidney Cancer |
| 4 X | Poor Response to Oral Vitamin D |
| 3 X | Ear infection |
| 2 X | MS |
| 2 X | Colorectal Cancer |
| 2 X | Prostate Cancer -in those with dark skins |
| 1.3 X | Infertility |
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:
Dark Skin25 ; Depression 17 ; Diabetes 39 ; Obesity 12 ; Hypertension 35 ; Breathing 29 ; Omega-3 30 ; Vitamin D Receptor 18 - All items in category Infant/Child
606 items - breastfed 887 items as of Jan 2018
- Preeclampsia 825 items as of Jan 2018
- Pre-term 4710 items as of Dec 2018
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items as of Aug 2020
- postpartum depression 208 items as of Aug 2018
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 794 as of Feb 2020
- Search Vitamin D Life for "Assisted reproduction" 33 items as of Feb 2017
- Fertility and Sperm category listing has
109 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Download the PDF from Vitamin D Life
Vitamin D-binding protein (VDBP), the main carrier of vitamin D, has recently been implicated in reproductive health and pregnancy outcomes including endometriosis, polycystic ovary syndrome (PCOS), pre-eclampsia, and gestational diabetes mellitus (GDM). Improved methods for measuring VDBP and an increased understanding of its role in biological processes have led to a number of newly published studies exploring VDBP in the context of pregnancy. Here, we synthesize the available evidence regarding the role of VDBP in reproductive health and pregnancy, and we highlight areas requiring further study. Overall, low levels of maternal serum VDBP concentrations have been associated with infertility, endometriosis, PCOS and spontaneous miscarriage, as well as adverse pregnancy outcomes including GDM, pre-eclampsia, preterm birth and fetal growth restriction. However, increased VDBP concentration in cervicovaginal fluid has been linked to unexplained recurrent pregnancy loss and premature rupture of membranes. Some genetic variants of VDBP have also been associated with these adverse outcomes. Further studies using more accurate VDBP assays and accounting for ethnic variation and potential confounders are needed to clarify whether VDBP is associated with reproductive health and pregnancy outcomes, and the mechanisms underlying these relationships
During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020Printer Friendly PDF this page! Follow this page for updates347 visitors, last modified 20 May, 2020, This page is in the following categories (# of items in each category)Pregnancy750 Vit D Binding Protein 141 Attached files
ID Name Comment Uploaded Size Downloads 13827 VDBPTable B.jpg admin 20 May, 2020 13:50 213.16 Kb 74 13826 VDBPTable A.jpg admin 20 May, 2020 13:47 723.46 Kb 72 13825 VDBP F1.jpg admin 20 May, 2020 13:25 27.87 Kb 96 13824 Vitamin D-Binding Protein in Pregnancy.pdf PDF 2020 admin 20 May, 2020 13:25 536.17 Kb 72 See any problem with this page? Report it (FINALLY WORKS) - All items in category Infant/Child