Dietary and plasma magnesium and risk of coronary heart disease among women.
J Am Heart Assoc. 2013 Mar 18;2(2):e000114. Doi: 10.1161/JAHA.113.000114.
Chiuve SE, Sun Q, Curhan GC, Taylor EN, Spiegelman D, Willett WC, Manson JE, Rexrode KM, Albert CM.
Center for Arrhythmia Prevention, Department of Medicine Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
BACKGROUND: Magnesium is associated with lower risk of sudden cardiac death, possibly through antiarrhythmic mechanisms. Magnesium influences endothelial function, inflammation, blood pressure, and diabetes, but a direct relation with coronary heart disease (CHD) risk has not been established.
METHODS AND RESULTS: We prospectively examined the association between dietary and plasma magnesium and risk of CHD among women in the Nurses' Health Study. The association for magnesium intake was examined among 86 323 women free of disease in 1980. Information on magnesium intake and lifestyle factors was ascertained every 2 to 4 years through questionnaires.
Through 2008, 3614 cases of CHD (2511 nonfatal/1103 fatal) were documented.
For plasma magnesium, we conducted a nested case-control analysis, with 458 cases of incident CHD (400 nonfatal/58 fatal) matched to controls (1:1) on age, smoking, fasting status, and date of blood sampling.
Higher magnesium intake was not {quite} associated with lower risk of total CHD (P-linear trend=0.12) or nonfatal CHD (P-linear trend=0.88) in multivariable models.
However, magnesium intake was inversely associated with risk of fatal CHD.
The RR comparing quintile 5 to quintile 1 of magnesium intake was 0.61 (95% CI, 0.45 to 0.84; P-linear trend=0.003). The association between magnesium intake and risk of fatal CHD appeared to be mediated partially by hypertension. Plasma magnesium levels above 2.0 mg/dL were associated with lower risk of CHD, although not independent of other cardiovascular biomarkers (RR, 0.67; 95% CI, 0.44 to 1.04).
CONCLUSIONS: Dietary and plasma magnesium were not associated with total CHD incidence in this population of women. Dietary magnesium intake was inversely associated with fatal CHD, which may be mediated in part by hypertension.
PMID: 23537810
CHD vs plasma Magnesium
virtually all data points are within the dashed lines
PDF is attached at the bottom of this page
Possible reasons by Vitamin D Life
- Magnesium directly reduces coranary heart disease
- Magnesium reduces Calcium deposits in the blood vessels
- Magnesium required to get the benefits of vitamin D
See also Vitamin D Life
- Vitamin D might deal with atherosclerosis – Jan 2011
- Atherosclerosis associated with low vitamin D – June 2011
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Overview Magnesium and vitamin D which has the following table
Magnesium and Vitamin D are synergistic, that is, increasing one helps the other.
| Magnesium | not Magnesium | |
| Vitamin D | Magnesium or Vitamin D Aging, Amytrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder; Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease. Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis; Peripheral vascular disease; Pregnancy-related problems,Rheumatoid Arthritis; Sports-related problems, | Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, Hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, P in - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports |
| Not Vitamin D | Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity; Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapsee, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitis, Sound Sensitivity; TMJ; Toxic Shock; Violence | Neither ALL OTHER DISEASES |