Chemo only as needed for Prostate Cancer is working well - March 2019

A CLEVER NEW STRATEGY FOR TREATING CANCER, THANKS TO DARWIN Wired Magazine

Do not try to kill Prostate Cancer, but just keep it contained - dose only when needed

Constant dosing and the cancer evolves how to avoid the chemotherapy (carpet bombing)
war analogy - constant bombing and the enemy evolves a defense - bumkers
with infrequent dosing it does not have evolutionary pressure to learn from
classic example of the math that plotted how growing populations of snowshoe hares fuel the rise of the lynx that feed on them

They describe how tumor cells compete with healthy cells for energy resources such as the glucose that fuels them.

"Tumor cells vie against each other for resources. They turned to game theory to plot this dynamic and plugged the numbers into the Lotka-‑Volterra equations."

Prostate Cancer pilot test - 1/2 the drug dosing as needed lived 27 months instead of 16 months for constant dosing
they probably just considered the late stage/intense prostate cancer

Very simple bang-bang control equation( like a simple air conditioner control)
Start Dose when PSA>X, Stop does when PSA <X/2
FDA cannot obeject - since FDA does not police the dosing schedule, only the dosing amount
Wonder if the dose were changed continously instead of bang-bang
might have better response with lower energy (drug) cost

"at least 128 different DNA mutations in various kidney tumor samples from one patient, for instance. There's some evidence that the more mutations there are, the more aggressive a cancer tends to be, suggesting a higher chance that one of these DNA changes will confer tumor cells with the potential to be drug-resistant. Given technological advances, it’s not too far-fetched to think that within the coming decade, doctors will routinely measure the amount of mutations in their patients’ tumors"

"During treatment breaks, the thinking goes, the fuel-hungry resistant cells are outcompeted by drug-‑sensitive cells, which need fewer resources to thrive."

Cancer category starts with the following

• Cancer 211 items Overview Cancer and vitamin D
• After Cancer Diagnosis 84 items
• Bladder Cancer 25 items
• Breast Cancer 223 items Overview Breast Cancer and Vitamin D
• Colon Cancer 116 items Overview Cancer-Colon and vitamin D
• Leukemia 16 items
• Liver Cancer 14 items
• Lung Cancer 49 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 22 items
• Other Cancer 55 items
• Ovarian Cancer 21 items
• Pancreatic Cancer 55 items
• Prostate Cancer 92 items Prostate Cancer and Vitamin D studies
• Skin Cancer 110 items Overview Suntans melanoma and vitamin D
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Cancer is leading cause of death - Vitamin D and Receptor activators help
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 15 articles
• Breast Cancer and VDR 15 articles
• Colon Cancer and VDR 9 articles
• Prostate Cancer and VDR 6 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation

Chemotherapy might be amplified by vitamin D has the following chart