A Longitudinal Study for the Effect of Vitamin D Adjunct to Chemotherapy on Non-Metastatic Breast Cancer Patients after Mastectomy
Breast Cancer Reports DOI : http://dx.doi.org/10.7243/2057-1631-6-1
Trial injected 200,000 IU of vitamin D monthly for 4 months to half of the participants
Chemo typically increases BMD decline by 2X to 3X
- Injection category listing has
53 items along with related searches - Loading doses are similar to injection is if far less expensive
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154 items along with related searches - Cancer - Breast category listing has
223 items along with related searches - Cancer - after diagnosis category listing has
84 items along with related searches - Metastatic Cancer is maybe reduced by vitamin D - 5 articles
- Bone fractures 2.8 X more likely among cancer survivors (perhaps low vitamin D) – Dec 2017
- Overview Fractures and vitamin D
- Cancers and Cancer therapyboth reduce levels of Vitamin D
- Reduced Vitamin D levels increase risk of bone fracture
Items in both categories Cancer - Breast and Cancer- after diagnosis are listed here:
- Breast cancer chemo made more women vitamin D insufficient, even 6 months later– 2019
- Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019
- Chemotherapy for Breast Cancer lowers Vitamin D levels – Oct 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast cancer reoccurred twice as often if have less than 20 ng of vitamin D – Dec 2018
- Following breast cancer 100,000 IU Vitamin D doses helped a lot (standard of care 400 IU daily did not) – RCT July 2016
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017
- Perhaps Breast Cancer tumors can be reduced by 7 weeks of 50,000 IU Vitamin D – 2023
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Breast Cancer Chemotherapy dropped Vitamin D levels by 6 nanograms – Nov 2015
- Breast cancer chemotherapy benefits from highest vitamin D levels – June 2014
- 85 percent less risk of death from Breast Cancer when vitamin D levels higher than 30 ng – May 2012
- Vitamin D after breast cancer diagnosis
- Breast Cancer Chemotherapy initially decreases vitamin D levels – May 2012
- Aromatase inhibitor chemotherapy after breast cancer not associated with vitamin D levels – Dec 2011
- Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011
- Vitamin D and breast cancer radiation
- Vitamin D3 sensitizes breast cancer to radiation treatment - increasing cancer cell death – May 2010
Download the PDF from Vitamin D Life
Note: Those getting Vitamin D
1) Lost weight
2) Reduce BMI
3) Reduced lumors (Vitamin D is known to improve Chemo)
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BMD INCREASED in those getting Vitamin D instead of decreasingEhab I. Mohamed1*, Azza M. Helal2,3, Noha M. Awad4, Gihane I. Khalil5, Amani M. Bayoumi6 and Nadia A. Abd El Moneim7
*Correspondence: Ehab I. Mohamed eimohamed at yahoo.com; ehab.abdo at alexu.edu.eg
1. Medical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.Background: Women with BC are at increased risk for the development of osteoporosis and skeletal fractures. We investigated the effect of CAF chemotherapy alone and adjunct to vitamin D treatment on biochemical markers of bone formation and on segmental and total bone mineral density (BMD) for non-metastatic breast cancer (NMBC) postmenopausal women who had gone through a mastectomy.
Methods: The study population was comprised of 200 NMBC women who were divided into two equal groups; before and after treatment with CAF chemotherapy alone and before and after treatment with CAF+Vitamin D treatment protocols. Other 100 healthy participants served as the Control group. All participant women were subjected to blood biochemical analysis and segmental and total BMD measurements using Dual-energy X-ray Absorptiometry technique.
Results: We found that CAF chemotherapy alone had no effect on women’s body weight, BMI, tumor marker CA15-3, PTH, ALP and Ca levels as compared to the initial state, while CAF+Vitamin D adjunct treatment caused significant reductions in their levels as compared to the initial state and Healthy Controls. We found also that CAF chemotherapy alone had no effect on plasma levels of P and Vitamin D as compared to initial state yet, CAF+Vitamin D adjunct treatment caused significant elevations in their levels as compared to the initial state and Healthy Controls.
Conclusions: Vitamin D may decrease the risk of BC recurrence by decreasing risk factors like body weight and serum levels of CA15-3, PTH, ALP, and Ca, thus increasing segmental and total BMD and decreasing the risk of osteoporosis.
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