Role of Vitamin D in the Outcome of Ischemic Stroke- A Randomized Controlled Trial
Journal of Clinical and Diagnostic Research 2017 February. DOI: 10.7860/JCDR/2017/24299.9346
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017
Also, with injection there is no worry about the person failing to take a periodic dose - Note lac = 100,000, so 6 lac = 600,000
Items in both categories Stroke and Intervention are listed here:
- Stroke not prevented by just 2,000 IU of vitamin D plus 840 mg Omega-3 (VITAL) – Feb 2020
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Ischaemic stroke – Vitamin D doubled survival (Injection and 60,000 IU per month) – RCT Aug 2016
Download the PDF from Vitamin D Life
Shuba Narasimhan, Prakash Balasubramanian
1. Associate Professor, Department of Physiology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India. 2. Professor, Department of Neurology, PSG Hospitals, Coimbatore, Tamil Nadu, India.
Dr. Shuba Narasimhan, Associate Professor, Department of Physiology, PSG Institute of Medical Sciences and Research, Peelamedu, Coimbatore-641004, Tamil Nadu, India. E-mail: shubaphysio at gmail.com
- PDF describing SSS
SSS= 0 = worst, SSS= 58= no stroke
Introduction: Vitamin D deficiency has reached epidemic proportions in India with prevalence rates of 70-100% in the general population. Low vitamin D levels are associated with worse outcomes in ischemic strokes. The outcome of stroke after vitamin D replenishment has not been much studied.
Aim: To compare the stroke outcome between patients receiving vitamin D supplementation and patients without vitamin D supplementation by Scandinavian Stroke Scale (SSS) and thus, to assess the long term outcome of ischemic stroke patients with low vitamin D level by supplementation of vitamin D.
Materials and Methods: This is a non blinded randomized controlled trial conducted in ischemic stroke patients. The patients were divided into two groups (A and B ) where Group A received a single dose of 6 lac IU of Cholecalciferol Intramascular (IM) injection and Group B were not given vitamin D. Finally 30 patients in each group were analyzed. SSS was applied to evaluate the stroke severity at the onset and at the follow up after three months in both groups. The difference in SSS was analyzed using SPSS software. Independent t-test was applied and p-value < 0.05 was taken as significant.
Results: Mean±SD of vitamin D levels in Group A and Group B were 17.98±3.81ng/ml and 18.44±4.69 ng/ml respectively. Mean±SD of SSS at time of admission and after three months for Group A was 32.50±11.61 and 38.89±8.34; and for Group B 35.82±8.56 and 38.32±7.10. The difference in SSS from time of admission and after three months, in Group A (6.39±4.56) and Group B (2.50±2.20) were analyzed statistically and found to be highly significant (p<0.001).
Conclusion: The results showed that there is a significant improvement in the stroke outcome after three months in those patients who were supplemented with vitamin D. Thus screening for vitamin D deficiency in stroke patients is essential and vitamin D replenishment will improve the stroke outcome.