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Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

See also Vitamin D Life

Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 88 items

20 Most-visited pages in Depression category in Vitamin D Life

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7681 Depression 120040
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1052 Hypothesis - Reduce insomnia with vitamin D 16008
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4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 15889
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3608 Suicide 2X more likely with low vitamin D (in military) – Jan 2013 14225
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6789 Omega-3 prevents PTSD and some mood disorders - Aug 2015 13927
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5274 Tricyclic antidepressants reduce the active but not the normally measured form of vitamin D in seniors – April 2014 13717
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4187 99 percent of psychiatric population had less than 30 ng of vitamin D – June 2013 13036
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5075 Serotonin regulated by Vitamin D – part 1 autism – Feb 2014 12935
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Pages listed in BOTH the categories Depression and Omega-3


In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.


Created by admin. Last Modification: Wednesday November 22, 2017 03:00:42 GMT-0000 by admin. (Version 3)