Serum vitamin D levels can be predictive of psoriasis flares up after COVID-19 vaccination: a retrospective case control study
EFront Med (Lausanne). 2023 May 25;10:1203426. doi: 10.3389/fmed.2023.1203426.
mmanouil Karampinis 1, George Goudouras 1, Niki Ntavari 1, Dimitrios Petrou Bogdanos 2, Angeliki-Victoria Roussaki-Schulze 1, Efterpi Zafiriou 1
Introduction: Many patients with chronic inflammatory dermatosis such as psoriasis usually ask about the safety of COVID-19 vaccination and if it would affect the course of their disease. Indeed, many case reports, case series and clinical studies, reporting psoriasis exacerbation following vaccination against COVID-19, were published during the pandemic. Also, many questions arise regarding the existence of exacerbating factors of these flare ups, including environmental triggers such as the insufficiency of vitamin D levels.
Methods: This is a retrospective study that measures alterations in psoriasis activity and severity index (PASI) not exceeding 2 weeks after the first and second dose of COVID-19 vaccinations in the reported cases and assesses whether such changes have any association with patients' vitamin D levels. We retrospectively reviewed the case records of all patients with a documented flare up after COVID-19 vaccination in our department as well as those who did not, during a year.
Results: Among them, we found 40 psoriasis patients that had reported vitamin D levels in the form of 25-hydroxy-vitamin D within 3 weeks after vaccination, including 23 with exacerbation and 17 without exacerbation. Performing χ2 and t-test controls for psoriasis patients with and without flare-ups, a statistically significant dependence emerged in the seasons of summer [χ2(1) = 5.507, p = 0.019], spring [χ2(1) = 11.429, p = 0.001] and in the categories of vitamin D [χ2(2) = 7.932, p = 0.019], while the mean value of vitamin D for psoriasis patients who did not have exacerbation
- (31.14 ± 6.67 ng/mL) is statistically higher [t(38) = 3.655, p = 0.001]
than the corresponding value of psoriasis patients who had an exacerbation
- (23.43 ± 6.49 ng/mL).
Discussion: This study indicates that psoriasis patients with insufficient (21-29 ng/mL) or inadequate (<20 ng/mL) levels of vitamin D are more prone to postvaccination aggravation of the disease while vaccination in summer, a period with the most extent photo-exposition, can be a protective factor.
Download the PDF from Vitamin D Life
Note: Possible error - more reporting of Vitamin D level in those getting a flare
Vitamin D Life – Psoriasis category contains
Some of the- Psoriasis is most strongly associated with low vitamin D (15 things were evaluated) – July 2022
- Long-term Psoriasis cured by 30,000 to 60,000 IU of Vitamin D daily (pictures and video) – early 2022
- Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
- Low Vitamin D plus psoriasis equals 8 times more likely to die – Dec 2020
- UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
- Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
- Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
- 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
VitaminDwiki COVID infections and vaccinations decrease Vitamin D – many studies
Vaccination
- COVID vaccinations resulted in big increase in metabolic disorders - Nov 2023
- COVID vaccination health problems - Campbell, Yale Nov 2023
- Hypothesis: Multiple COVID vaccinations reduce Vitamin D, resulting in Excess Deaths, etc. - Oct 2023
- Following COVID vaccination 31% had neurological problems (Italy) – Oct 2023
- Autoimmune diseases caused in first day after COVID Vaccination - Oct 2023
- Immune System tolerance is inversely related to the number of COVID vaccinations (PubMed analysis) - Oct 2023
- Hospital utilization Australia (NSW) 1415 Vaccinated, 0 unvaccinated - Dec 2022
- Vaccinated children have more health problems – any vaccination, not just COVID
- Multiple COVID vaccinations might increase Cancer Incidence - many studies
- Vaccine Clinical Trial - cardiovascular death 3.7X more likely if vaccinated - preprint Sept 2023
- Myocarditis, Pericarditis 2X more likely if had COVID vaccination in previous 30 days - meta-analysis June 2023
- COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
- 800x Higher Incidence of Myocardial Injury After Booster Vaccination - July 2023
- 74% of autopsies were found to be related to COVID vaccination (from 44 studies) – Lancet July 2023
- More psoriasis flares following second COVID vaccination if lowish Vitamin D – May 2023
- Long-COVID 2.2X more-likely if had 2 COVID vaccinations - Dec 2022
Vaccination and/or Infection
- COVID infections or vaccinations may increase Multiple Sclerosis (if low D) - several studies
- 50% increase in Cancer deaths (age 15-44) since before COVID - Nov 2023
- Early puberty during pandemic (low vitamin D) - several studies
- Excess deaths - 5 possible reasons - many studies
- Low heart rate variability (bad) is associated with low Vitamin D and COVID – many studies
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
- Increased risk of many neuro problems after COVID (1.4 X youths, 1.2X seniors) – Aug 2022
- COVID increased seniors risk of Alzheimer's by 1.7X in the next year- Sept 2022
- Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
- Athletes who had been COVID infected had lower Vitamin D levels – July 2023
- COVID, Vitamin D, Drs. Grimes and Campbell - Jan 2024 has the following chart
Hypothesis: The body consumes Vitamin D each time the immune system is activated
The "GREEN" person started with a high level of Vitamin D
This assumes no vitamin D supplementation by supplements, sun, etc.
See also Vitamin D Life
- Micronutrients such as vitamin D should improve vaccine effectiveness (and decrease side effects) – April 2022
- COVID vaccination makes 6X more antibodies in those having good levels of both vitamin D and Iron – June 2021
- Vitamin D might augment COVID-19 vaccines – 6 papers as of Dec 2021
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