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Dental caries 1.22 X more likely if Vitamin D Deficient – meta-analysis Oct 2023

Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis

BMC Oral Health . 2023 Oct 19;23(1):768. doi: 10.1186/s12903-023-03422-z.
Zizhan Li 1 2, Xiao Wei 3, Zhongjun Shao 3, Huan Liu 4, Shizhu Bai 5

Background: Vitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children.

Methods: Four electronic databases were searched by two investigators including PubMed, Embase, Web of Science, and Cochrane Library. Dental caries results were presented as either prevalence or based on the index of primary and permanent teeth/surfaces with decaying, missing, and filled areas, while vitamin D levels were determined through laboratory testing. Two researchers independently selected studies, collected information, assessed risk of bias, and evaluated the study quality. Any disagreements were resolved through discussion.

Results: A total of 13 studies were included, comprising 5 cross-sectional studies, 5 cohort studies, 3 case-control studies, all of which had high methodological quality. Our meta-analysis showed that children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels, with a relative risk (RR) of 1.22 and a 95% confidence interval (CI) of 1.18 to 1. 25. Further subgroup analysis according to the three types of studies showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (cohort studies: 62%; cross-sectional studies, 19%; and case-control studies, 5%). Additionally, according to age, subgroup analysis also showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (permanent teeth studies, 28%; deciduous teeth studies, 68%; and mixed dentition studies 8%).

Conclusions: Levels of 25 (OH) D have been found negatively associated with dental caries in children, indicating that low vitamin D levels may be considered a potential risk factor to this dental disease.
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    21+ Vitamin D Life pages with CARIES or DECAY in the title

    This list is automatically updated

    Items found: 24
    Title Modified
    Dental Caries 2.2 X more likely if low Vitamin D (NHANES) – Feb 2024 17 Feb, 2024
    Early Childhood Caries 1.4 times more likely if 20-30 ng of Vitamin D – meta-analysis Jan 2024 03 Feb, 2024
    Caries in deciduous teeth about 2X more likely if low vitamin D – Review Nov 2023 25 Nov, 2023
    Dental caries 1.22 X more likely if Vitamin D Deficient – meta-analysis Oct 2023 20 Oct, 2023
    Caries (tooth decay) and Vitamin D - many studies 09 Aug, 2023
    Dental caries associated with poor Vitamin D receptor – 2016 09 Aug, 2023
    Severe infant caries 10X higher risk if low vitamin D (under 14 ng) - Dec 2021 14 Dec, 2021
    How tooth decay due to vitamin D deficiency came to be treated with Fluoride - Dec 2021 10 Dec, 2021
    More dental caries in children who have less than 30 ng of Vitamin D – Review Sept 2020 02 Jan, 2021
    Increased dental decay if take Calcium without Magnesium – Feb 2020 22 Feb, 2020
    Vitamin D cut dental caries in half 80 years ago – meta-analysis 2013 29 Oct, 2019
    3X fewer infant dental caries if good level of vitamin D while pregnant – April 2014 07 Aug, 2019
    No tooth decay in children with adequate Vitamin D (small study) – June 2018 27 Aug, 2018
    Dental caries cut in half by vitamin D, review of 24 old clinical trials – Nov 2012 21 Aug, 2018
    Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017 13 Jul, 2017
    Severe tooth decay in children unless supplemented with Vitamin D drops – Oct 2013 17 Jul, 2016
    Genes associated with low vitamin D also associated with childhood tooth decay – Dec 2015 21 Dec, 2015
    Dental Caries risk in children cut in half if more than 20 nanogram of Vitamin D – Nov 2015 11 Nov, 2015
    Off topic : Fluoridation fails to reduce tooth decay but succeeds in causing health problems – Dec 2014 31 Oct, 2015
    Tooth decay and bleeding gums associated with low vitamin D in postmenopausal women – Dec 2012 06 Aug, 2013
    Children with severe caries were 2X more likely to have inadequate vitamin D – July 2012 10 Nov, 2012
    Vitamin Deficiency Underlies Tooth Decay – 2009 and 1931 24 Sep, 2012
    UVB and Vitamin D might decrease dental caries better than fluoride – July 2011 11 Aug, 2012
    Vitamin D and minimum cereal minimized tooth decay – in 1932 12 Dec, 2010

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