Vitamin D and Clinical Cancer Outcomes: A Review of Meta-Analyses
JBMR Plushttps://doi.org/10.1002/jbm4.10420
John D Sluyter,1 ©JoAnn E Manson,2,3 and Robert Scragg1 ®
- 1School of Population Health, University of Auckland, Auckland, New Zealand
- 2Department of Medicine, Brigham and Women;s Hospital, and Harvard Medical School, Boston, MA, USA
- 3Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Note: This umbrella review appears to assume Cancer deaths due to low vitamin D getting to cells only occur when vitamin D levels are less than 30 ng. This ignores cancer deaths at higer levels of vitamin D for some cancers and ignores cancer deaths when Vitamin D is limited in getting to cells - by genes, etc.
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
22 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation
The Meta-analysis of CANCER and Vitamin D
- USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Non-Hodgkin Lymphoma 20 percent more likely if low UV – meta-analysis April 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015
- Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013
- Vitamin D has a complex relationship with Cancer – meta-analysis July 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
The Meta-analysis of Breast Cancer and Vitamin D
- Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023
- Breast Cancer risk - meta-analysis of 50 studies - Dec 2019
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013
- Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013
- 3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Meta-analysis not find low vitamin D years before breast cancer – Aug 2010
- Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
- Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010
- Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010
The Meta-analysis of Bladder Cancer and Vitamin D
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016
- Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015
- Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015
- Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014
The Meta-analysis of Colon Cancer and Vitamin D
- 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023
- Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
- Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021
- Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020
- Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019
- Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015
- Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015
- Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011
- Non-cancer colon growths 7 percent less likely with each 10 ng increase in vitamin D – Oct 2011
- Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011
- Colon polyps reduced 15 percent by increasing vitamin D by 20 ng – meta-analysis June 2011
- Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
The Meta-analysis of Prostate Cancer and Vitamin D
- 1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018
- Meta-graphs of vitamin D and Cancer – Dec 2011
- Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011
- 16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011
- Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010
Download the PDF from Vitamin D LifeThe relationship between vitamin D status or supplementation and cancer outcomes has been examined in several meta-analyses.To address remaining knowledge gaps, we conducted a systematic overview and critical appraisal of pertinent meta-analyses. For metaanalyses of trials, we assessed their quality using AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews), strength of associations using umbrella review methodology and credibility of evidence using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) criteria. Meta-analyses of observational studies reported inverse associations of 25OHD with risk of cancer incidence and cancer mortality and, particularly for colorectal cancer, fulfilled some of Bradford-Hill7s causation criteria. In meta-analyses of trials, vitamin D supplementation did not affect cancer incidence. However, we found credible evidence that vitamin D supplementation reduced total cancer mortality risk, with five out of six meta-analyses reporting a relative risk (RR) reduction of up to 16%: RR, 0.84 (95% CI, 0.74-0.95). The strength of the association, however, was classified as weak. This was true among metaanalyses of high, moderate, and lower quality (AMSTAR-2-rated). Trials did not include large numbers of vitamin D-deficient participants; many tested relatively low doses and lacked sufficiently powered data on site-specific cancers. In conclusion, meta-analyses show that, although observational evidence indicates that low vitamin D status is associated with a higher risk of cancer outcomes, randomized trials show that vitamin D supplementation reduces total cancer mortality, but not cancer incidence. However, trials with larger proportions of vitamin D-insufficient participants and longer durations of follow-up, plus adequately powered data on site- specific common cancers, would provide further insight into the evidence base.
- © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020Printer Friendly Follow this page for updates4157 visitors, last modified 31 Dec, 2020, This page is in the following categories (# of items in each category) - Breast Cancer and VDR