Table of contents
- Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis - Oct 2022
- Similar meta-analysis: only 2 studies used > 3,000 IU daily ==> 4X reduction in mortality - March 2023
- Vitamin D Life Mortality pages with CANCER in the title (35 as of Nov 2022)
- Examples of successful Cancer trials: 4,000 IU, measure D levels, add Omega-3, etc.
Vitamin D supplementation for the prevention of total cancer incidence and mortality: An updated systematic review and meta-analysis - Oct 2022
Heliyon . 2022 Oct 28;8(11):e11290. doi: 10.1016/j.heliyon.2022.e11290
Huzaifa Ahmad Cheema 1 2 , Maurish Fatima 2 , Abia Shahid 1 2 , Oumnia Bouaddi 3 , Anas Elgenidy 4 , Aqeeb Ur Rehman 2 , Salah Eddine Oussama Kacimi 5 , Mohammad Mehedi Hasan 6 , Ka Yiu Lee 7
Introduction: Previous randomized controlled trials (RCTs) and meta-analyses of RCTs evaluating vitamin D supplementation for the prevention of cancer incidence and mortality have found inconsistent results and no meta-analysis has assessed the quality of the evidence available. We, therefore, aimed to perform an updated meta-analysis by including recent large-scale RCTs and assessing the quality of the pooled evidence.
Methods: We searched several databases and trial registers from inception to April 2022. We used a random-effects model to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs). We used the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) considerations to evaluate the certainty of evidence.
Results: We included 13 RCTs in our study. Vitamin D supplementation had no effect on the risk of total cancer incidence (RR 0.99, 95% CI: 0.94-1.04; I 2 = 0%), total cancer mortality (RR 0.93, 95% CI: 0.84-1.03; I 2 = 24%) and total mortality (RR 0.92, 95% CI: 0.82-1.04; I 2 = 36%). The overall quality of evidence was high for all outcomes.
Discussion: Vitamin D supplementation is ineffective in reducing total cancer incidence and mortality in largely vitamin D-replete older adult populations. Future research should be based on populations with a higher prevalence of vitamin D deficiency and should involve more extended follow-up periods.
Study protocol: PROSPERO database, CRD42021285401.
 Download the PDF from Vitamin D Life
Similar meta-analysis: only 2 studies used > 3,000 IU daily ==> 4X reduction in mortality - March 2023
Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials
 Download the PDF from Vitamin D Life
Vitamin D Life Mortality pages with CANCER in the title (35 as of Nov 2022)
This list is automatically updated
Examples of successful Cancer trials: 4,000 IU, measure D levels, add Omega-3, etc.
- Cancer risk reduced 65 percent by vitamin D levels greater than 40 nanograms – April 2016
- Multiple Myeloma (blood cell cancer) treated by vitamin D - many studies
- Prostate Cancer might be treated by 4,000 IU of vitamin D and aspirin – RCT 2021
- Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015
- Low risk Prostate Cancer decreased with 4,000 IU of vitamin D – July 2012
- 2,000 IU of vitamin D and Omega-3 reduced Cancer death rate bv 40% (normal weight) – VITAL RCT Nov 2020
- Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
- Overview Cancer-Colon and vitamin D has the following Colon Cancer Prevention chart