APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018

Using the APOE4 Gene to Determine Alzheimer's Care Dr. Issacson Dec 2018

• Includes 3 minute video
• “Tobacco plus the APOE4 gene presses the fast-forward button towards Alzheimer's disease”
• “There were a variety of other studies that showed that people with two copies of the APOE4 gene should possibly start thinking about what their vitamin D level is.[7] Having an elevated vitamin D level—[or even high-normal] to, say, 50 to 70 in one study—actually may be even more protective for people with two copies of the APOE4 gene.”
• “…. recent studies[9] have actually shown that people with the APOE4 gene may respond preferentially to omega-3 fatty acid supplementation. However, the key here is that it takes 2.5 years for the amount of omega-3s to really replenish the brain.[10]”

References

1. Berkowitz CL, Mosconi L, Rahman A, Scheyer O, Hristov H, Isaacson RS. Clinical application of APOE in Alzheimer's prevention: a precision medicine approach. J Prev Alzheimers Dis. 2018;5:245-252.  Download the PDF from Vitamin D Life both Omega-3 and Vit D may prevent Alz APOE4
2. Solomon A, Turunen H, Ngandu T, et al. Effect of the apolipoprotein E genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomized clinical trial. JAMA Neurol. 2018;75:462-470. Abstract
3. Kivipelto M,Rovio S, Ngandu T, et al. Apolipoprotein E ε4 magnifies lifestyle risks for dementia: a population-based study. J Cell Mol Med. 2008;12:2762-2771. Abstract
4. Etnier JL, Caselli RJ, Reiman EM, et al. Cognitive performance in older women relative to ApoEepsilon4 genotype and aerobic fitness. Med Sci Sports Exerc. 2007;39:199-207. Abstract
5. Head D, Bugg JM, Goate AM, et al. Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol. 2012;69:636-643. Abstract
6. Brown BM, Peiffer JJ, Taddei K, et al. Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. 2012;18:875. Abstract
7. Mosconi L, Murray J, Tsui WH, et al. Mediterranean diet and magnetic resonance imaging- assessed brain atrophy in cognitively normal individuals at risk for Alzheimer's disease. J Prev Alzheimers Dis. 2014;1:23-32. Abstract
8. Martinez-Lapiscina EH, Galbete C, Corella D, et al. Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial. Genes Nutr. 2014;9:393. Abstract
9. Durazzo TC, Mattsson N, Weiner MW. Interaction of cigarette smoking history with APOE genotype and age on amyloid level, glucose metabolism, and neurocognition in cognitively normal elders. Nicotine Tob Res. 2016;18:204-211. Abstract
10. Maddock J, Cavadino A, Power C, Hypponen E. 25-Hydroxyvitamin D, APOE ε4 genotype and cognitive function: findings from the 1958 British birth cohort. Eur J Clin Nutr. 2015;69:505-508. doi: 10.1038/ejcn.2014.201

• Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018
• Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018
• Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018
• Brain is helped by Omega-3 during all phases of life – Aug 2018
• Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015
• Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018
• Types of evidence that Vitamin D helps brain problems - 2014

Overview Alzheimer's-Cognition and Vitamin D starts with

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
  • It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  There are 13+ Alzheimer’s meta-analyses in Vitamin D Life
  There are 97+ Alzheimer’s studies in Vitamin D Life
  Dementia is associated with low vitamin D - many studies 50+ studies
  16+ studies in both categories Cognitive and Omega-3

Items in both categories Cognitive and Omega-3 are listed here: