ADHD significantly treated by daily Magnesium plus weekly Vitamin D – RCT April 2021

The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

BMC Pediatrics volume 21, Article number: 178 (2021)
Mostafa Hemamy, Naseh Pahlavani, Alireza Amanollahi, Sheikh Mohammed Shriful Islam, Jenna McVicar, Gholamreza Askari & Mahsa Malekahmadi

Background
Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in people with ADHD. The aim of this study is to determine the effect of vitamin D and magnesium supplementation on mental health in children with ADHD.
Methods
We conducted a randomized, double blind, placebo-controlled clinical trial of 66 children with ADHD. Participants were randomly allocated to receive both vitamin D (50,000 IU/week) plus magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8-weeks. Strengths and difficulties questionnaire was used to evaluate children’s mental health at baseline and the end of the study.
Results
After eight weeks of intervention, the serum levels of 25-hydroxy-vitamin D3 and magnesium increased significantly in the intervention group compared with the control group. Also, children receiving vitamin D plus magnesium showed a significant reduction in

• emotional problems (p = 0.001),
• conduct problems (p = 0.002),
• peer problems (p = 0.001),
• prosocial score (p = 0.007),
• total difficulties (p = 0.001),
• externalizing score (p = 0.001), and
• internalizing score (p = 0.001)

compared with children treated with the placebo.
Conclusion
Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with ADHD. However, further well-designed studies with a larger sample size are needed.
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Vitamin D Life - 4 studies in both categories ADHD and Magnesium

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ADHD and Vitamin D Deficiency category contains (as of Nov 2022)

• ADHD = Attention Deficit Hyperactivity Disorder    Wikipedia
• ADHD children have much lower levels of vitamin D
• ADHD is more likely if low vitamin D in early pregnancy
• Less sun is associated with more ADHD (season and latitude)
• The ADHD rate has increased a lot in past few decades - especially for adults
• Vitamin D levels have dropped a lot in the past few decades
• There are many positive observational studies of Vitamin D and ADHD
• ADHD shares risk factors with Autism and many other diseases
     Low Vitamin D, Low Omega-3, Low Magnesium, Low UVB (= high latitude or winter)

Magnesium and mental illness chart

Which is in Overview Magnesium and vitamin D