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5000 IU Vitamin D daily resulted in lower health care costs - RCT Oct 2023

Healthcare Costs and Healthcare Utilization Outcomes of Vitamin D3 Supplementation at 5000 IU Daily During a 10.9 month Observation Period within a Pragmatic Randomized Clinical Trial

Nutrients 2023, 15(20), 4435; https://doi.org/10.3390/nu15204435
Patrick J. LaRiccia, Teresa Cafaro, Dibato John, Noud van Helmond, Ludmil V. Mitrev, Brigid Bandomer, Tracy L. Brobyn, Krystal Hunter, Satyajeet Roy, Kevin Q. Ng, Helen Goldstein, Alan Tsai, Denise Thwing, Mary Ann Maag, Myung K. Chung

Vitamin D insufficiency has been linked to multiple conditions including bone disease, respiratory disease, cardiovascular disease, diabetes, and cancer. Observational studies indicate lower healthcare costs and healthcare utilization with sufficient vitamin D levels. The secondary aims of our previously published pragmatic clinical trial of vitamin D3 supplementation were comparisons of healthcare costs and healthcare utilization. Comparisons were made between the vitamin D3 at 5000 IU supplementation group and a non-supplemented control group.
Costs of care between the groups were not statistically different.
Vitamin D3 supplementation reduced healthcare utilization in four major categories:

  • hospitalizations for any reason
    • (rate difference: -0.19 per 1000 person-days, 95%-CI: -0.21 to -0.17 per 1000 person-days, p < 0.0001);
  • ICU admissions for any reason
    • (rate difference: -0.06 per 1000 person-days, 95%-CI: -0.08 to -0.04 per 1000 person-days, p < 0.0001);
  • emergency room visits for any reason
    • (rate difference: -0.26 per 1000 person-days, 95%-CI: -0.46 to -0.05 per 1000 person-days, p = 0.0131; and
  • hospitalizations due to Covid-19
    • (rate difference: -8.47X10−3 per 1000 person-days, 95%-CI: -0.02 to -1.05X10−3 per 1000 person-days, p = 0.0253).

Appropriately powered studies of longer duration are recommended for replication of these utilization findings and analysis of cost differences.
 Download the PDF from Vitamin D Life

Study waited 60 days before cost monitoring, however, Cancers etc. will not respond for years.

Anticipate far lower costs if the cost monitoring started at 12 months and lasted for >36 months

Vitamin D group had 13% less hospital cost than the control group
GroupTotal Hospital $# of people daysAverage $/day
Control $41,109,649 590,000 $69.67
Intervention$2,318,500 37,900$61.16

However, the abstract says: "Costs of care between the groups were not statistically different. "

It actually takes >150 days for response to plateau, not 60 days (in this study)

Image

Is 50 ng of vitamin D too high, just right, or not enough (5,000 IU ==> 50 ng)

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors

799 items in Intervention - Vitamin D by date

50+ Vitamin D Life pages with 5,000 in the title

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Items found: 51
Title Modified
5,000 IU of Vitamin D - many studies 22 Oct, 2023
5000 IU Vitamin D daily resulted in lower health care costs - RCT Oct 2023 21 Oct, 2023
Depression reduced if take more than 5,000 IU of vitamin D daily – umbrella meta-analysis – Jan 2023 06 Jan, 2023
Model of Vitamin D and metabolites reaction to 5,000 IU daily – Sept 2022 04 Sep, 2022
5,000 U daily raised Vitamin D a bit and helped COVID-19 a bit – RCT June 2021 14 Jul, 2021
Elite sports teams adding 5,000 IU of vitamin D weekly did not see much benefit (no surprise) – April 2021 15 Apr, 2021
5000 IU of vitamin D in daily bread resulted in 50 ng and improved quality of life– May 2014 20 Mar, 2021
People with Multiple Sclerosis taking at least 5,000 IU of Vitamin D felt much better – April 2021 06 Feb, 2021
Faster Soccer sprints by teens from 5,000 IU of vitamin D for just 70 days – Aug 2019 23 Aug, 2020
College swimmers helped by daily 5,000 IU of Vitamin D in the fall – RCT Feb 2020 13 Aug, 2020
Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020 25 Jul, 2020
Response to 150,000 IU vitamin D once vs 5,000 IU daily – RCT May 2014 10 Jul, 2020
Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU (but need more)– April 2020 17 Apr, 2020
Diabetes helped by 5,000 IU of Vitamin D – RCT Sept 2019 30 Dec, 2019
Vitamin D 5,000-8,000 IU and Omega-3 2.5 grams– Life Extension Nov 2019 19 Oct, 2019
5,000 IU Vitamin D daily resulted in many benefits after 3 months (US soldiers) – RCT March 2019 01 Sep, 2019
Diabetics and prediabetics helped by 5,000 IU of Vitamin D for 6 months– RCT July 2019 29 Jul, 2019
7 ng less response by Multiple Sclerosis patients to 5,000 IU of vitamin D – Aug 2015 30 Dec, 2018
Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018 10 Jul, 2018
Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018 17 Jun, 2018
Far more Vitamin D in breast milk from a 150,000 IU dose than from daily 5,000 IU – RCT May 2018 21 Mar, 2018
Skin whitening cream (RD) may cause blotchy skin, 5,000 Vitamin D can treat it – RCT Feb 2018 06 Feb, 2018
Dairy cattle have 70 ng of vitamin D if supplementation equal to 5,000 IU for human – Dec 2016 23 Apr, 2017
Professional sports team takes 5000 IU vitamin D and wins championship 24 Mar, 2017
5,000 IU daily was just enough vitamin D for Irish athletes in the winter – March 2013 16 Mar, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Infection fighting ability increased with 5,000 IU Vitamin D daily – April 2015 10 Jul, 2016
Athletic performance and recovery benefits of Vitamin D (4000-5000 IU and Vitamin K) – Aug 2015 01 Mar, 2016
Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations (5,000 IU) – Feb 2016 05 Feb, 2016
Hypothesis being tested: 5000 IU prevent second autistic child - May 2010 02 Feb, 2016
5,000 IU Vitamin D was not enough to reduce preeclampsia but did help future infant – RCT April 2014 15 Oct, 2015
Multiple Sclerosis web survey: 82 percent take vitamin D (2000-5000 IU), strong association with latitude - Aug 2015 05 Aug, 2015
Childhood migraine in Vitamin D deficient children reduced 6X by addition of daily 5,000 IU and amitriptyline – April 2014 03 Mar, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Iran giving seniors 5,000 IU of vitamin D - monthly unfortunately - March 2015 02 Mar, 2015
Crohn’s helped by 5000 IU vitamin D – April 2013 17 Feb, 2015
5,000 IU of vitamin D (in bread) was great – should have continued forever – Oct 2013 23 Jul, 2014
Defining normal level of vitamin D (need 4000-5000 IU) - Heaney Spring 2013 26 May, 2014
5000 IU vitamin D3 added daily to bread raised blood levels to 50 ng – 2009 16 May, 2014
Hearts responded to stress better after 5,000 IU of vitamin D for a month - March 2014 11 Mar, 2014
5,000 IU recommended by Vitamin D Council - Dec 2013 16 Dec, 2013
Vitamin D causes sarcoidosis in 1 in 5000 people 18 Sep, 2013
5,000 IU vitamin D helped UK professional athletes in the winter – Oct 2012 28 Jul, 2013
5000 IU Vitamin D3 with some cofactors 08 Jun, 2013
Type II Diabetes not reduced by 3 months of 5000 IU of vitamin D – RCT Jan 2013 08 Jan, 2013
Vitamin D repletion = 2000 IU daily for adults and 5000 IU daily for seniors May 2010 13 Oct, 2012
Needed 5,000 IU to achieve 30 ng of vitamin D in 3 months – March 2012 05 May, 2012
5000 to 10000 IU vitamin D helped MS in a pilot study – March 2012 30 Mar, 2012
Patients older than 65 needed 5,000 IU vitamin D daily – May 2010 25 Dec, 2011
5000 IU raised vitamin D levels 10 ng but did not raise cognition in young adults – Nov 2011 18 Nov, 2011
USANA found 5000 IU resulted in 50 ng - Winter 2010 24 Sep, 2011

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20188 Health Care costs 5,000 IU.pdf admin 05 Oct, 2023 530.52 Kb 78