Calcidiol

Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also

• Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
• Tests for Vitamin D 156 items
• Calcitriol 56 items
• Injection 62 items
• Forms of Vitamin D 106 items
• Response to Vitamin D - many studies 166 as of April 2023
• Nanoemulsion Vitamin D is faster and better - many studies
  • Response to Nanoemulstion Vitamin D swished in the mouth appears to start in 2 hours
• Calcidiol is available only by prescription and is expensive
• Calcidiol - daily dose has fast response, but weekly might be better - March 2018

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Getting Vitamin D into your body has the following chart

Here are all the Calcidiol articles

Calcidiol is available only by prescription and is expensive

Thirty 25ug capsules for $21
If you believe that calcidiol is 4X more potent than Vitamin D then each capsule has the equivalent of
   4,000 (4 X 40 X 25) IUs of vitamin D.
The cost of 4,000 IUs of vitamin D is about 2 cents
The cost of calcitriol is thus approximately 35 X more than Vitamin D3 (21/30)/0.02

Calcidiol - daily dose has fast response, but weekly might be better - March 2018

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens.
Osteoporos Int. 2017 Nov;28(11):3239-3249. doi: 10.1007/s00198-017-4180-3
Minisola S1, Cianferotti L2, Biondi P1, Cipriani C1, Fossi C2, Franceschelli F2, Giusti F2, Leoncini G2, Pepe J1, Bischoff-Ferrari HA3, Brandi ML4.

 Download the PDF from Vitamin D Life
Daily high dose raised blood levels quickly

FGF23 - similar large daily dose and weekly dose

1,25 similar response to all treatments

Least Calcium lost in Urine = weekly

RATIONALE: Calcidiol can be employed to correct vitamin D deficiency.

MAIN RESULTS: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism.

SIGNIFICANCE: Calcidiol supplementation is effective and safe.

INTRODUCTION:
The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis. Despite cholecalciferol (vitamin D3) is the most commonly used drug for vitamin D supplementation, the more hydrophilic compound calcidiol (25-hydroxyvitamin D3) can be employed at daily, weekly, and monthly regimens to reach in the short term the target levels of serum 25-hydroxyvitamin D [25(OH)D]. In the administration of different doses of calcidiol pharmacokinetic study (ADDI-D study), the efficacy and safety of daily and weekly dosages of calcidiol were tested.

METHODS:
A total of 87 Caucasian, community-dwelling, postmenopausal women, aged 55 years or older, with vitamin D inadequacy (serum 25(OH)D levels <30 ng/ml, with mean 25(OH)D below 20 ng/ml, namely 16.5 ± 7.5 ng/ml) were randomized to receive three different dosages of calcidiol: 20 μg/day, 40 μg/day, and 125 μg/week for 3 months. The attained level of serum 25(OH)D was selected as primary endpoint to assess efficacy, while other parameters of mineral metabolism, (serum calcium, parathyroid hormone, phosphate, FGF23, urinary calcium, and markers of bone turnover) were assessed as secondary endpoints to establish safety.

RESULTS:
In all the three groups, serum 25(OH)D values significantly and promptly rose and plateaued above the 30 ng/ml threshold remaining within safety interval after 14 days of treatment, with similar efficacy for the similar daily and weekly dose regimens. The different dosages were also equally effective in controlling secondary hyperparathyroidism. No significant changes in calcium and phosphate metabolism and in bone turnover markers were observed for any of the treatments, confirming the safety of this compound.

CONCLUSIONS:
The results of this study demonstrate the short- and mid-term efficacy and safety on core parameters of mineral metabolism of different daily or weekly dosages of calcidiol when used to treat vitamin D inadequacy or deficiency in postmenopausal women. Further studies are needed to assess falls as primary outcome of calcidiol supplementation.