Ivermectin and COVID-19 - many studies

c19ivermectin.com

https://c19ivermectin.com/

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CHAIRMAN OF TOKYO MEDICAL ASSOCIATION TELLS DOCTORS TO PRESCRIBE IVERMECTIN FOR COVID TREATMENT - 90 second video, Aug 26, 2021

9+ Vitamin D Life pages have IVERMECTIN in the title

This list is automatically updated

Ivermectin raises levels of vitamin D (by decreasing CYP3A4) - 6 studies

1. Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - 2014   PDF
2. Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes
   • Xenobiotica, . 1998 Mar;28(3):313-21. doi: 10.1080/004982598239597
3. Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects   March 2021   PDF
4. Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice? - July 2019 https://doi.org/10.1007/s00467-018-4030-3
   • 
5. CYP3A4 Induction by Rifampin: An Alternative Pathway for Vitamin D Inactivation in Patients With CYP24A1 Mutations -2017 [|FREE PDF]
   • 
6. Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)

Note: Ivermectin treats river blindness, which is also treated by Vitamin D

Compare Ivermectin and vitamin D

Both are heavily supported by both observations and clinical trials
Not clear which is best
Note: Ivermectin raises vitamin D levels/ (see 6 studies further down this page)

Mikki Willis, Pierre Kory - The War on Ivermectin - 12 minute video Dec 2023

Rumble

The War on Ivermectin (an overview) - May 2023

Dr. Malone Substack

Australia had banned Invermectin use for COVID in Sept 2021, Reconsidering in Sept 2022

URL

Australia again ALLOWS Ivermectin to be used for any health problem - April 2023

Ivermectin substantially reduced COVID infection, hospitalization, death (India)- Sept 2022

Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction in COVID- 19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects
Cureus 14(8): e28624. DOI 10.7759/cureus.28624

Background
We have previously demonstrated that ivermectin used as prophylaxis for coronavirus disease 2019 (COVID- 19), irrespective of the regularity, in a strictly controlled citywide program in Southern Brazil (Itajai, Brazil), was associated with reductions in COVID-19 infection, hospitalization, and mortality rates. In this study, our objective was to determine if the regular use of ivermectin impacted the level of protection from COVID- 19 and related outcomes, reinforcing the efficacy of ivermectin through the demonstration of a dose- response effect.

Methods
This exploratory analysis of a prospective observational study involved a program that used ivermectin at a dose of 0.2 mg/kg/day for two consecutive days, every 15 days, for 150 days. Regularity definitions were as follows: regular users had 180 mg or more of ivermectin and irregular users had up to 60 mg, in total, throughout the program. Comparisons were made between non-users (subjects who did not use ivermectin), and regular and irregular users after multivariate adjustments. The full city database was used to calculate and compare COVID-19 infection and the risk of dying from COVID-19. The COVID-19 database was used and propensity score matching (PSM) was employed for hospitalization and mortality rates.

Results
Among 223,128 subjects from the city of Itajai, 159,560 were 18 years old or up and were not infected by COVID-19 until July 7, 2020, from which 45,716 (28.7%) did not use and 113,844 (71.3%) used ivermectin. Among ivermectin users, 33,971 (29.8%) used irregularly (up to 60 mg) and 8,325 (7.3%) used regularly (more than 180 mg). The remaining 71,548 participants were not included in the analysis. COVID-19 infection rate was 49% lower for regular users (3.40%) than non-users (6.64%) (risk rate (RR): 0.51; 95% CI: 0.45-0.58; p < 0.0001), and 25% lower than irregular users (4.54%) (RR: 0.75; 95% CI: 0.66-0.85; p < 0.0001). The infection rate was 32% lower for irregular users than non-users (RR: 0.68; 95% CI: 0.64-0.73; p < 0.0001). Among COVID-19 participants, regular users were older and had a higher prevalence of type 2 diabetes and hypertension than irregular and non-users. After PSM, the matched analysis contained 283 subjects in each group of non-users and regular users, between regular users and irregular users, and 1,542 subjects between non-users and irregular users. The hospitalization rate was reduced by 100% in regular users compared to both irregular users and non-users (p < 0.0001), and by 29% among irregular users compared to non-users (RR: 0.781; 95% CI: 0.49-1.05; p = 0.099). Mortality rate was 92% lower in regular users than non-users (RR: 0.08; 95% CI: 0.02-0.35; p = 0.0008) and 84% lower than irregular users (RR: 0.16; 95% CI: 0.04-0.71; p = 0.016), while irregular users had a 37% lower mortality rate reduction than non-users (RR: 0.67; 95% CI: 0.40-0.99; p = 0.049). Risk of dying from COVID-19 was 86% lower among regular users than non-users (RR: 0.14; 95% CI: 0.03-0.57; p = 0.006), and 72% lower than irregular users (RR: 0.28; 95% CI: 0.07-1.18; p = 0.083), while irregular users had a 51% reduction compared to non-users (RR: 0.49; 95% CI: 0.32-0.76; p = 0.001).

Conclusion
Non-use of ivermectin was associated with a 12.5-fold increase in mortality rate and a seven-fold increased risk of dying from COVID-19 compared to the regular use of ivermectin. This dose-response efficacy reinforces the prophylactic effects of ivermectin against COVID-19.
 Download the PDF from Vitamin D Life

Ivermectin shows ‘antiviral effect’ against COVID (RCT- Japan) Jan 31, 2022

Ivermectin shows ‘antiviral effect’ against COVID, Japanese company says Reuters
Apparently Kowa Co. Ltd. 1000 patient Phase 3 clinical trial TrialSiteNews Jan 31
no details were given

Hypothesis: Ivermectin works by improving the gut microbiome - Dec 2022

Trial Site News Dec 15

• . . . . suggest heightened levels of Bifidobacterium may reduce not only inflammation levels but also TNF- α function thus contributing to “calming the cytokine storm of SARS-CoV-2 infection.”

See also

• Microbiome-Based Hypothesis on Ivermectin’s Mechanism in COVID-19 - July 2022 https://doi.org/10.3389/fmicb.2022.952321 FREE PDF
• Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases - RCT Feb 2022 https://doi.org/10.1038/s41467-022-28658-1 FREE PDF
• Ivermectin (IVM) Possible Side Activities and Implications in Antimicrobial Resistance and Animal Welfare: The Authors’ Perspective - Jan 2022 https://doi.org/10.3390/vetsci9010024 FREE PDF

A series of 4 blog posts on Ivermectin - including censorship Feb-March 2022

1) Ivermectin Part 1: The Very Unusual Paper
2)
Ivermectin Part 2: A Very Unusual Business
3)Ivermectin Part 3: The People Behind the Curtain
(3.1)Part 1: An Unacknowledged Influence

• 3.2)Part 2: The Conflicts of Interest of those who discredited Ivermectin
• 3.3)Part 3: Who is Andrew Owen?

4) Ivermectin Part 4: Censorship, controversy and attacks March 23. 2022

Some Ivermectin Videos

• History of Ivermectin Dec 2021 10 minute video followed by discussion
  • found in soil bacteria, became top-selling drug for Veterinarians
  • Approved for humans in 1987, 4 billion doses so far,
  • single annual dose stopped river blindness, 2015 Nobel prize,
• Dr. Pierre Kory, Ivermectin, and COVID (Let’s help end the pandemic.) Feb 25. 2 hours, the same interviewer
• Covid, Ivermectin and the Crime of the Century Kory - June 1, 2021?
  • The first 5 minutes appear to be blank
• Dr. Campbell asks why Ivermectin is not being considered - video, Israel RCT June 15, 2021
  • Includes overview of recent successful Randomized Clinical Trial in Israel
    • 2.6X better reduction in viral load than placebo
• Those taking Ivermectin for COVID were 3X less likely to die (1,000 people, 18 months) – March 2022 Campbell Video March 6
• 32 Ivermectin and COVID-19 questions answered - Video May 31, 2021Mobeen Syed 22 minutes

Dr. Campbell pointed out the new Pfizer drug and Ivermectin work in the same way Nov 2021 - video was removed from Facebook

New Pfizer drug and ivermectin Nov 9, 2021
Alternative facts Nov 11, 2021
Facebook of his video was removed after journalists review. NOT a peer review

Ivermectin COVID-19 effectivity 86%, meta-analysis Aug 2021

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
 Download the PDF from Vitamin D Life
One of the authors routinely has made reviews of drugs for WHO, but WHO refused to look at Ivermectin
Sept 2021 video interview of the author,Theresa Lawrie

Weekly Ivermectin prevents COVID-19 - Feb 2021

Is ivermectin ready to be part of a public health policy for COVID-19 prophylaxis?
 Download the PDF from Vitamin D Life

Similar to weekly vitamin D dosing, which provides far more benefits

Goa (1.8 million, India) to give Ivermectin every 5 days to all residents - May 11, 2021

Forbes
"...12 mg of Ivermectin for a period of five days as prophylaxis to protect against Covid-19"
"...Goa—one of India’s smallest states by population—has witnessed a recent surge in Covid-19 cases and on Tuesday it reported 3,124 new cases and 75 fatalities on Tuesday evening."

1 cent of Ivermectin decreased risk of COVID-19 by half (India healthcare workers) - Feb 2021

Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study
 Download the PDF from Vitamin D Life
Video by Dr. john Cambell on the study - May 6, 2021

Ivermectin RCT in Israel: 2.6X more likely for outpatient infection to go away - preprint May 2021

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial
doi: https://doi.org/10.1101/2021.05.31.21258081

Background Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection.

Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at recruitment and then every two days. Primary endpoint was reduction of viral-load on the 6th day (third day after termination of treatment) as reflected by Ct level>30 (non-infectious level). The primary outcome was supported by determination of viral culture viability.

Results Eighty-nine patients were eligible (47 in ivermectin and 42 in placebo arm). Their median age was 35 years. Females accounted for 21·6%, and 16·8% were asymptomatic at recruitment. Median time from symptom onset was 4 days. There were no statistical differences in these parameters between the two groups.

On day 6, 34 out of 47 (72%) patients in the ivermectin arm reached the endpoint, compared to 21/ 42 (50%) in the placebo arm (OR 2·62; 95% CI: 1·09-6·31). In a multivariable logistic-regression model, the odds of a negative test at day 6 was 2.62 time higher in the ivermectin group (95% CI: 1·06–6·45). Cultures at days 2 to 6 were positive in 3/23 (13·0%) of ivermectin samples vs. 14/29 (48·2%) in the placebo group (p=0·008).

Conclusions There were significantly lower viral loads and viable cultures in the ivermectin group, which could lead to shortening isolation time in these patients.
 Download the PDF from Vitamin D Life

Ivermectin reduced COVID-19 deaths in Peru by 14X - March 19, 2021

Ivermectin reduced COVID-19 deaths in Peru by 14X, after new president halted it, the death rate increased 13X – March 18, 2021

Top Yale Doctor/Researcher: ‘Ivermectin works,’ including for long-haul COVID - March 22, 2021

Top Yale Doctor/Researcher: ‘Ivermectin works,’ including for long-haul COVID TrialSiteNews
Prevention, treatment, and long-haul
"“When you have people that can’t breathe for five, six, eight, nine months and they tried multiple drugs and supplements with no success, and you give them ivermectin,” Dr. Santin said of long-haul patients, “and you see that they start immediately feeling better, this is not placebo. This is real.”

Ivermectin - Long-COVID

• IVERMECTIN IN LONG-COVID PATIENTS A RETROSPECTIVE STUDY - Feb 2021
  • Download the PDF from Vitamin D Life
• Several Facebook pages - > 1,000 Long-haul using Ivermectin at each page
• Protocol of treating long-haul with Ivermetin Mercola July 2021
  • I-RECOVER — a long-term management protocol for long-haul syndrome

Ivermectin reduced Vaccination Injury - Jan 2024

Campbell and Robert Clancy - 58 minute video
sSeems to decrease clotting ==> increase oxygen update
00:00:00 - Intro
00:00:01 - New medical findings on post-vaccine syndrome
00:05:59 - treatment for low oxygen saturation
00:12:22 - Patient case study, symptoms, improvement.
00:18:33 - In silico drug screening, ivermectin, spike protein
00:24:18 - Pain mechanisms, fatigue illness, autonomic disorder
00:30:36 – Iva, mechanism and treatment
00:36:52 - Repurposed drugs, virus replication, drug mechanisms
00:42:45 - Testing hypotheses, gut microbiome, immune resilience
00:48:41 - Stopped hydroxychlorin, treatment, patient experiences.

NOT Using Ivermectin Is Unethical And Immoral - Jan 2021

Not Using Ivermectin, One Year In, Is Unethical And Immoral TrialSiteNews
The family pushed to have Ivermectin given to the 80-year old woman in ICU
She got so much benefit that she left the ICU 48 hours later
The non- ICU portion of the hospital refused to continue the Ivermectin
The family had to sue the hospital, and the judge forced the hospital to continue the Ivermectin
She was released to a rehabilitation facility soon after

7X less morbidity in those African countries using Ivermectin - March 26, 2021

Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?
Preprint - doi: https://doi.org/10.1101/2021.03.26.21254377
 Download the PDF from Vitamin D Life

Background: Scientists have so far been unable to determine the reason for the low number of COVID-19 cases in Africa.

Objective: To evaluate the impact of ivermectin interventions for onchocerciasis on the morbidity, mortality, recovery, and fatality rates caused by COVID-19.

Method: A retrospective statistical analysis study of the impact of ivermectin against COVID-19 between the 31 onchocerciasis-endemic countries using the community-directed treatment with ivermectin (CDTI) and the non-endemic 22 countries in Africa. The morbidity, mortality, recovery rate, and fatality rate caused by COVID-19 were calculated from the WHO situation report in Africa. We investigated the onchocerciasis endemic 31 countries and the non-endemic 22 countries. Statistical comparisons used by the Welch test of them in the two groups were made.

Results: The morbidity and mortality were statistically significantly less in the 31 countries using CDTI. The recovery and fatality rates were not statistically significant difference. The average life expectancy was statistically significantly higher in the non-endemic countries.

Conclusions: The morbidity and mortality in the onchocerciasis endemic countries are lesser than those in the non-endemic ones. The community-directed onchocerciasis treatment with ivermectin is the most reasonable explanation for the decrease in morbidity and fatality rate in Africa. In areas where ivermectin is distributed to and used by the entire population, it leads to a significant reduction in mortality.

Countries using prophylactic chemotherapy with Ivermectin have far fewer COVID-19 infections - Jan 2021

A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin
Int J Antimicrob Agents. 2021 Jan;57(1):106248. doi: 10.1016/j.ijantimicag.2020.106248.
Martin D Hellwig 1, Anabela Maia 2
 Download the PDF from Vitamin D Life

COVID-19 incidence worldwide

Another chart shows similar reduction for African countries

As COVID-19 (coronavirus disease 2019) continues to rapidly spread throughout the world, the incidence varies greatly among different countries. These differences raise the question whether nations with a lower incidence share any medical commonalities that could be used not only to explain that lower incidence but also to provide guidance for potential treatments elsewhere. Such a treatment would be particularly valuable if it could be used as a prophylactic against SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) transmission, thereby effectively slowing the spread of the disease while we await the wide availability of safe and effective vaccines.
Here, we show that countries with routine mass drug administration of prophylactic chemotherapy including ivermectin have a significantly lower incidence of COVID-19. Prophylactic use of ivermectin against parasitic infections is most common in Africa and we hence show that the reported correlation is highly significant both when compared among African nations as well as in a worldwide context. We surmise that this may be connected to ivermectin's ability to inhibit SARS-CoV-2 replication, which likely leads to lower infection rates. However, other pathways must exist to explain the persistence of such an inhibitory effect after serum levels of ivermectin have declined. It is suggested that ivermectin be evaluated for potential off-label prophylactic use in certain cases to help bridge the time until a safe and effective vaccine becomes available.

Mercola Jan 25, 2021

Mercola

• "The data shows the ability of the drug Ivermectin to prevent COVID-19, to keep those with early symptoms from progressing to the hyper-inflammatory phase of the disease, and even to help critically ill patients recover. - FLCCC Alliance" FLCCC = Frontline COVID-19 Critical Care Alliance
• "Like hydroxychloroquine, ivermectin is an antiparasitic drug with a well-documented safety profile and “proven, highly potent, antiviral and anti-inflammatory properties.”12 It’s been on the market since 1981 and is on the World Health Organization’s list of essential medicines. It’s also inexpensive, with a treatment course costing less than $2 in countries such as India and Bangladesh"
•  FLCCC Press release Jan 7
•  FLCCC Clinital summary

NIH is no longer opposed to the use of Ivermectin - Jan 20, 2021

"The National Institutes of Health (NIH) has dropped its recommendation against the inexpensive antiparasitic drug ivermectin for treatment of COVID-19, and the agency now advises it can't recommend for or against its use, leaving the decision to physicians and their patients."
https://www.medscape.com/viewarticle/944440

Doctors Ask Arizona Gov to Facilitate COVID-19 Treatment with Ivermectin - Jan 26, 2021

Arizona chapter of American Physicians and Surgeons

Ivermectin protocol and experiences

https://covid19criticalcare.com/
Several Facebook pages - including Ivermectin and Long Haul

Use of Ivermectin did not change COVID-19 outcomes - meta-analysis Jan 29, 2021

Outcomes of Ivermectin in the treatment of COVID-19: a systematic review and metaanalysis

 Download the PDF from Vitamin D Life

Covid-19: Ivermectin’s politicization is a warning sign for doctors turning to orphan treatments

British Medical Journal April 1. 2021
Doctors are not permitted to use a drug that has been successfully used over a billion times for other health problems
Interesting that US doctors are permitted to use other drugs for off-label health problems,
   but not for this particular health problem, for which tens of billions of dollars have been invested (vaccines)
     lots to be gained by promoting vaccines, but virtually no one will gain by promoting potential pre-existing solutions

The Drug that Cracked Covid - Ivermectin May 2021

 Download the PDF from Vitamin D Life

Review of Evidence: Ivermectin helps - May 2021

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

 Download the PDF from Vitamin D Life

Ivermectin helped in Mexico City - May 2021

• Mexico City Wide Innovative Population-Level Study Administers Ivermectin-based Home Kits with Drastic Reduction in Hospitalizations May 8, 2021

Gave Ivermectin (several pills) to those with symptoms (but not in hospital)
"The Mexico City study team generated compelling results in that they reduced the pressures on hospital system by 52% to 76% depending on a number of factors."
COVID-19 hospitalizations

Bird = British Ivermectin Recomendation Development

https://bird-group.org/
Started after watching FLCC presentation to US senate in Dec 2020
BIRD hosted the first International Ivermectin for Covid Conference in May 2021 closing video

Additional groups trying to get Invermetin allowed/used

FLCCC Alliance,
World Doctors Alliance,
Médicos pela Vida Brazil),
Long Covid-19 Foundation (UK),
Covid Medical Network Australia,
https://ivmmeta.com/
https://www.e-bmc.co.uk/ strongly associated with BIRD

Ivermectin DID NOT decrease COVID-19 severity - RCT March 2021

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19 - A Randomized Clinical Trial
ivermectin, 300 μg/kg of body weight per day for 5 days
with mild disease and symptoms for 7 days or fewer (at home or hospitalized)
 Download the PDF from Vitamin D Life

The Scientific Misconduct Story Behind Ivermectin - Mercola Jan 2022

 Download the PDF from Vitamin D Life
Associated 9 minute Video

The Global Disinformation Campaign Against Ivermectin - The "Blitz"

Pierre Kory substack Nov 7, 2022

which is in The problems with healthcare in the U.S., following the disinformation playbook – Grant Dec 2017

- - - - Ivermectin, other than COVID

• Ivermectin used to fight Scabies TrialSite news Aug 2022
  • "“Our research shows MDA could reduce the prevalence of scabies by 90 percent after just one treatment, which could have a huge impact on children in the region."
  • Previous trial for 130,000 Fijians. was very successl, now uusing it for everyone
  • A mass drug administration (MDA) has been funded for all of the Solomon Islands
  • WebMD on Scabies

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