- 18+ Vitamin D Life pages with EPIGENETICS in the title
- Evidence in support of the Strong Epigenetic Theory of Aging - Oct 2020
- Vitamin D, COPD, and Epigenetics – Aug 2011
- See also Vitamin D Life
- There have been
38621 visits to this page 18+ Vitamin D Life pages with EPIGENETICS in the title
This list is automatically updated
Items found: 19Evidence in support of the Strong Epigenetic Theory of Aging - Oct 2020
https://yurideigin.medium.com/death-becomes-her-or-why-aging-is-an-epigenetic-program-c55a32fd8c74|Medium.com]
Mice have 800,000 sites, of which just over 20% change significantly with age.- "...there are 10x (!) more gene pathways where methylation increases with age, which usually correlates with a decrease in gene expression, than pathways where the opposite happens"
Vitamin D, COPD, and Epigenetics – Aug 2011
Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics.
Front Pharmacol. 2011;2:50
Sundar IK, Rahman I.
Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center Rochester, NY, USA.Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environmental agents (airborne particulates). Recent studies have highlighted the role of vitamin D and vitamin D receptor (VDR) in regulation of several genes that are involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis.
Vitamin D has also been implicated in reversal of steroid resistance and airway remodeling, which are the hallmarks of chronic obstructive pulmonary disease (COPD) and severe asthma. VDR protein level is decreased in lungs of patients with COPD. VDR deficient mice develop an abnormal lung phenotype with characteristics of COPD, such as airspace enlargement and decline in lung function associated with increased lung inflammatory cellular influx, and immune-lymphoid aggregates formation.
Dietary vitamin D may regulate epigenetic events, in particular on genes which are responsible for COPD susceptibility. Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism.
This review provides an update on the current knowledge and understanding on vitamin D, and susceptibility of chronic lung diseases in relation to the possible role of epigenetics in its molecular action. Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.
 Download the PDF from Vitamin D Life.See also Vitamin D Life
- All items in category Genetics and vitamin D
332 items - All items in category Breathing and vitamin D
446 items - Overview Asthma and Vitamin D
- COPD fought by Vitamin D - many studies
There have been
38621 visits to this page Epigenetics and Vitamin D – many studies29897 visitors, last modified 18 Dec, 2023, This page is in the following categories (# of items in each category) - All items in category Breathing and vitamin D
- There have been