The impact of vitamin D on cancer: A mini review
The Journal of Steroid Biochemistry and Molecular Biology. Volume 231, July 2023, https://doi.org/10.1016/j.jsbmb.2023.106308
Gerbenn Seraphin a, Sandra Rieger a b, Martin Hewison c, Enrico Capobianco d, Thomas S. Lisse a b e
Highlights
- Vitamin D cancer research has increased substantially in recent years.
- Vitamin D continues to show positive anti-cancer effects against many types of cancer.
- Demographic studies recommend vitamin D supplementation to prevent cancer.
- Vitamin D modulates immunological function, anti-metastasis, and tumorigenesis, according to mechanistic research.
In this review, we summarize the most recent advances in vitamin D cancer research to provide molecular clarity, as well as its translational trajectory across the cancer landscape. Vitamin D is well known for its role in regulating mineral homeostasis; however, vitamin D deficiency has also been linked to the development and progression of a number of cancer types. Recent epigenomic, transcriptomic, and proteomic studies have revealed novel vitamin D-mediated biological mechanisms that regulate cancer cell self-renewal, differentiation, proliferation, transformation, and death. Tumor microenvironmental studies have also revealed dynamic relationships between the immune system and vitamin D's anti-neoplastic properties. These findings help to explain the large number of population-based studies that show clinicopathological correlations between circulating vitamin D levels and risk of cancer development and death. The majority of evidence suggests that low circulating vitamin D levels are associated with an increased risk of cancers, whereas supplementation alone or in combination with other chemo/immunotherapeutic drugs may improve clinical outcomes even further. These promising results still necessitate further research and development into novel approaches that target vitamin D signaling and metabolic systems to improve cancer outcomes.
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16 Major Cancers in Vitamin D Life (April 2023)
- Cancer (256+) Overview
- After diagnosis (97+)
- Bladder (25+)
- Bone (8+)
- Breast (241+) Overview
- Colon (134+) Overview
- Gastric (9+)
- Leukemia (18+)
- Liver (16+)
- Lung (53+) Overview
- Lymphoma (23+)
- Melanoma (43+)
- Multiple Myeloma (10+)
- Metastatic (17+)
- Other (59+) - many minor cancers also fought
- Ovarian (23+)
- Pallitive Care (10+)
- Pancreatic (54+)
- Prostate (97+) Overview
- Skin (116+) Overview
- Thyroid (7+)
See also: Overview Cancer and vitamin D, Cancer and Vitamin D - many studies
88+ Vitamin D Receptor pages with CANCER etc. in the Vitamin D Life title
Many cancers protect themselves by deactivating the VDR
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