Vaccination protected as much as 20 ng higher vitamin D (calves in this case)

Mycobacterium bovis vaccination and subsequent experimental infection outcomes are associated with changes in vitamin D status in dairy calves

JDS Commun. 2024 May 10;5(6):622-627. doi: 10.3168/jdsc.2024-0547

Rachel L Lee 1, Kieran G Meade 2, Shelley G Rhodes 3, Tom Ford 4, Ilias Kyriazakis 1

Investigations into the role of vitamin D (vitD) in the immune response of cattle are limited. The objectives of this study were therefore to investigate the association between circulating vitD concentration, tuberculosis (TB) vaccination, and Mycobacterium bovis infection outcomes in 24 dairy calves (<8 wk old) that were housed throughout and fed a BW-based allowance. The study design incorporated 2 phases: vaccination (experimental wk 0-52) and experimental infection phase (wk 52-65). Vaccinated calves (n = 12) received a subcutaneous injection of a live attenuated TB strain at wk 0, whereas unvaccinated ones (n = 12) were injected with saline.

All animals were infected with 7,600 cfu of M. bovis 52 wk postvaccination , and lung and lymph node tissues were assessed for pathology following euthanasia after wk 65. Blood samples were taken throughout wk 0 to 65. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using a commercial ELISA. A mixed-effects linear regression model revealed significantly higher 25(OH)D concentrations in the vaccinates postinfection (wk 65) compared with the nonvaccinates. Linear regression analysis between 25(OH)D concentration and the level of M. bovis-driven pathology revealed a negative linear relationship (i.e., higher concentrations were associated with lower pathology scores) irrespective of vaccination status. No correlation was detected between IFN-γ cytokine production and vitD concentration.

Overall, the results support an impactful role for vitD in the development of effective immunity of cattle against M. bovis. Gaining insight into the interaction between TB vaccination, M. bovis infection, and vitD could potentially guide the optimization of vaccination protocols and future TB control strategies.

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Vitamin D Life - studies in both categories Vet and Virus

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Over 715 Virus studies have Vitamin D in the title - here are 27 of them

1. Monkeypox and Vitamin D - several studies

2. Bird flu possible pandemic (Vitamin D can prevent it)- many studies

3. Measles and low Vitamin D, Vitamin A

4. Vitamin D preventing and treating COVID - 30,000 publications – Oct 2024

5. How Vitamin D helps the body fight viral infections such as COVID-19 – Sept 2024

6. COVID ICU use reduced by 42% if take more than 100,000 IU of vitamin D over two weeks – meta-analysis Sept 2024

7. Vitamin D helps the immune system fight COVID-19 – Sunil video Jan 2021

8. COVID-19 Vitamin D Overview - Sunil video and transcript - Dec 8, 2020

9. Many viral diseases can be fought by immune system-augmented Vitamin D - Sunil Aug 2024

10. Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024

11. Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT July 2024

12. 15.3 X fewer COVID deaths in those getting Vitamin D injections in ICU – RCT July 2024

13. Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis Jan 2022

14. COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024

15. COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024

16. Viral conjunctivitis much worse if low vitamin D in tears – April 2024

17. COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) - many studies

18. COVID maximum downregulation of Vitamin D receptor and CYP27B1 resulted in death - Feb 2024

19. Vitamin D: Viral infections, Infectious diseases, EBV and MS, Virus and Cancers – Grant March 2024

20. COVID infection (without hospitalization) – 1.7X more likely to die in 6 months if low Vitamin D – March 2024

21. COVID senior pneumonia deaths: 50% if low Vitamin D and unvaccinated vs 16% if Vitamin D or vaccinated – June 2023

22. 5 X less COVID infection of health care workers who took lots of vitamin D – meta-analysis Feb 2024

23. Long-COVID a month shorter if more than 20 ng of Vitamin D - Jan 2024

24. COVID deaths cut in half by a single dose of 600,000 IU of Vitamin D - RCT Jan 2024

25. HPV and Vitamin D - several studies

26. Feed Additives as Antiviral Agents: Probiotics, Vitamin D, Zn, Se, etc. - Dec 2023

27. All died of COVID with standard vitamin D, 25% survived if 10X more vitamin D (mice) – Dec 2023

Vitamin D Life - Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011

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