Autoimmune patients need 100-150 ng of Vitamin D - Dr. Gundry
80% Of Everyone is Deficient | The Immune-Boosting Vitamin Everyone's Missing!
Summary
(00:00–00:50) Vitamin D should be taken daily, not just for 30-day challenges. It's technically a hormone, not a vitamin, and research keeps revealing its wide-ranging importance.
(00:51–01:29) About 80% of new patients in Dr. Gundry's Southern California practice are vitamin D deficient, largely due to heavy sunscreen use, protective clothing, and sun avoidance.
(01:29–02:10) Darker skin acts as natural sunscreen, contributing to deficiency; a Brooklyn study found only 8% of the Black population there had normal vitamin D levels.
(02:10–02:45) Higher vitamin D levels are linked to greater gut microbiome diversity, which — like a rainforest ecosystem — correlates with better overall health.
(02:45–04:32) Vitamin D activates intestinal stem cells that repair the gut lining (only one cell thick). Without it, damaged cells don't get replaced, contributing to leaky gut.
(04:32–05:41) Vitamin D acts as a brake on an overactive immune system, telling it to calm down — relevant since ~80% of Gundry's practice is autoimmune patients, who often need very high doses to respond.
(06:14–07:44) UC San Diego researchers have not observed toxicity even at 40,000 IU/day and suggest 10,000 IU/day for the average adult. Quest Labs considers up to 150 ng/mL a normal blood level, contradicting the older "above 80 is toxic" teaching.
(08:12–09:50) Gundry targets blood levels of 100–150 ng/mL. He shares a case of a patient safely taking 50,000 IU/day (with normal calcium/kidney function) to reach that range; most people do fine at ~10,000 IU/day.
(10:16–11:59) He recounts two patients in their late 70s with levels around 270 ng/mL and no toxicity signs, who taught him vitamin D is a "longevity hormone" — later confirmed by his own reading.
(11:59–end) Highest vitamin D levels are associated with longest lifespans, likely via gut diversity, gut-wall repair, and immune regulation. He ends with a product plug for Gundry MD's vitamin D + K2 supplement.
Related in Vitamin D Life
- Some health problems are treated by very high dose vitamin D - video and summary
- Vitamin D: 40-70 ng is optimal, sometimes more is needed - Grant, Sunil, Pawel, Cheng
- What Each Vitamin D Level Actually Treats — From Rickets at 30 ng to MS at 150 ng
Autoimmune
- 60,000 IU of Vitamin D daily for 7 years treats many autoimmune diseases without toxicity (cofactors were used)
- How Vitamin D Cures Autoimmune Disease - Video Dec 2025
- Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases
- Number 1 Vitamin Deficiency in ALL Autoimmune Conditions - video*The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video
- Vitamin D Receptor is associated in over 58 autoimmune studies
the probable reason such high levels of vitamin D are needed