Postural Balance and Vitamin D Receptor Gene Polymorphism in Physically Independent Older Adults
International Conference on Applied Human Factors and Ergonomics. AHFE 2018:
Advances in Human Factors and Ergonomics in Healthcare and Medical Devices pp 397-404 |
https://doi.org/10.1007/978-3-319-94373-2_44
Regina Poli-Frederico Marcos Fernandes Rubens A. da Silva Karen Fernandes
G1 (44% ) = TT genotype group = poorer balance
G2 (56%) = TC or CC genotypes = better balance
Balance Test
Need more balance area (Center of Pressure)
for 1-legged stand: 14 vs 10
Sway more if TT VDR
Note: Falls are associated with low Vitamin D blood levels
The VDR (TT) restricts how of it actually gets to the cells
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
Falls and Fractures category contains the following summary
219 items in FALLS and FRACTURES - see also Overview Seniors and Vitamin D
- Overview Fractures and Falls and Vitamin D
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
Hip fracture
- Search Vitamin D Life for "HIP FRACTURE" 191 items not in PDF as of July 2020
- A call to action: Vitamin D for hip fracture – Holick July 2020
- Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020
- 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
- Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
- Fracture risk 40 percent higher risk if low Vitamin D - June 2019
- 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
Vitamin D Receptor category has the following
384 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDRCompensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D in the cells 13) Sulfroaphone and perhaps sulfur Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
PDF is available free at Sci-Hub 10.1007/978-3-319-94373-2_44
This study aimed to assess the association between VDR polymorphisms and postural balance in physically independent elderly. 142 elderly persons were enrolled at this case-control study. In order to assess the balance, the individuals performed three 30-s trials of one-legged stance balance test on a BIOMEC400 force-platform (EMG System of Brazil, SP Ltda.), following a standardized protocol (with 30 s of rest between each trial). The main balance parameters used for analysis were: center of pressure area (COP), sway velocity (cm/s) and frequency (s) in both the antero-posterior (A/P) and the medio-lateral (M/L) axes. The VDR TaqI polymorphism analysis was by PCR-RFLP. The case group showed lower values of COP, sway velocity in A/P and M/L axes (p = 0.0007). Similar data were observed regarding frequency in A/P (p = 0.04) and M/L axes (p = 0.03). Therefore, carriers of the “C” allele have a better postural balance when compared to individuals with “T” allele.References
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CrossRefGoogle ScholarVitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 20181934 visitors, last modified 02 Jul, 2018,