Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management
BMJ Open Heart 2020;7:e001356. doi: 10.1136/openhrt-2020-001356
Isabella D Cooper 1, Catherine A P Crofts 2, James J DiNicolantonio 3, Aseem Malhotra 4, Bradley Elliott1, Yvoni Kyriakidou1 and Kenneth H Brookler 5
Vitamin D Life had wondered for 8 years why Diabetes seemed to consume Vitamin D.
It appears that Insulin decreases the amount of vitamin D which gets to the blood
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
459 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 49 ; Meta-analysis 29 ; Obesity 26 ; Pregnancy 38 ; T1 (child) 36 ; Omega-3 10 ; Vitamin D Receptor 19 ; Genetics 10 ; Magnesium 19 Click here to see details
Items in both categories Diabetes and Virus are listed here:- Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020
- Hyperglycemic 2X more likely to have severe COVID-19 - Nov 2020
- Diabetes increases COVID-19 severity and COVID-19 creates Diabetes - Oct 2020
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
Items in both categories Gut and Probiotics are listed here:
- Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020
- Migraine Headache association with poor gut – Feb 2020
- Gut microbiome altered by many nutrients – such as Vitamin D – Jan 2020
- Strong interactions between Vitamin D and the gut microbiota via Butyrate and VDR – Dec 2019
- Prediabetics had different gut bacteria – April 2018
- Vitamin D, Gut Microbiota, and Chemo-radiation interactions – Dec 2019
- Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018
- Resveratrol, Metabolic Syndrome, and Gut Microbiota – Nov 2018
- Microbiome improvement by probiotics can be augmented with phages (gut, etc.)
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Gut microbiome massively changed by high dose vitamin D – July 2015
- Gut Microbiota: The Neglected Endocrine Organ (vitamin D not mentioned) – July 2014
- Reasons for low response to vitamin D
See also VItaminDWiki
- Gut-Friendly Vitamin D
- many forms of vitamin D apparently are gut-friendly, even without good bacteria
- How Vitamin D prevents Insulin Resistance – Sept 2020
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- How Vitamin D both prevents and treats insulin resistance (Diabetes) – April 2019
- Most Diabetics helped by Vitamin D (90 percent are deficient) – Nov 2019
- Low Magnesium associated with diabetes, etc. – meta-analysis 2016
- Low Level Laser Therapy greatly increased Vitamin D and Magnesium (for diabetics with nephropathy) – March 2019
- Perhaps the LLLT decreased insulin, which resulted in more Mg and Vitamin D
- How Vitamin D prevents Hyperglycemia – Sept 2020
 Download the PDF from Vitamin D Life
Risk factors for COVID-19 patients with poorer outcomes include pre-existing conditions: obesity, type 2 diabetes mellitus, cardiovascular disease (CVD), heart failure, hypertension, low oxygen saturation capacity, cancer, elevated: ferritin, C reactive protein (CRP) and D-dimer. A common denominator, hyperinsulinaemia, provides a plausible mechanism of action, underlying CVD, hypertension and strokes, all conditions typified with thrombi. The underlying science provides a theoretical management algorithm for the frontline practitioners.
Vitamin D activation requires magnesium.
Hyperinsulinaemia promotes:- magnesium depletion via increased renal excretion,
- reduced intracellular levels,
- lowers vitamin D status via sequestration into adipocytes and
- hydroxylation activation inhibition.
Hyperinsulinaemia mediates thrombi development via:
- fibrinolysis inhibition,
- anticoagulation production dysregulation,
- increasing reactive oxygen species,
- decreased antioxidant capacity via nicotinamide adenine dinucleotide depletion,
- haem oxidation and catabolism,
- producing carbon monoxide,
- increasing deep vein thrombosis risk and pulmonary emboli.
Increased haem-synthesis demand upregulates carbon dioxide production, decreasing oxygen saturation capacity. Hyperinsulinaemia decreases cholesterol sulfurylation to cholesterol sulfate, as low vitamin D regulation due to magnesium depletion and/or vitamin D sequestration and/or diminished activation capacity decreases sulfotransferase enzyme SULT2B1b activity, consequently decreasing plasma membrane negative charge between red blood cells, platelets and endothelial cells, thus increasing agglutination and thrombosis.
Patients with COVID-19 admitted with hyperglycaemia and/or hyperinsulinaemia should be placed on a restricted refined carbohydrate diet, with limited use of intravenous dextrose solutions. Degree/level of restriction is determined by serial testing of blood glucose, insulin and ketones. Supplemental magnesium, vitamin D and zinc should be administered. By implementing refined carbohydrate restriction, three primary risk factors, hyperinsulinaemia, hyperglycaemia and hypertension, that increase inflammation, coagulation and thrombosis risk are rapidly managed.
Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020119 visitors, last modified 13 Dec, 2020, This page is in the following categories (# of items in each category)Diabetes459 Vitamin D and Magnesium 260 Virus 434 Attached files
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