Combined Effect of Dynapenia (Muscle Weakness) and Low Vitamin D Status on Incident Disability.
J Am Med Dir Assoc. 2018 Aug 1. pii: S1525-8610(18)30326-8. doi: 10.1016/j.jamda.2018.06.006.
Items in both categories Seniors and Sports are listed here:
- Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020
- Less muscle loss associated with eating more fish (Omega-3, Vitamin D, Magnesium, etc) – Jan 2020
- My balance significantly improved at age 73 (perhaps Vitamin D, B12, or Omega-3) – Jan 2020
- Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019
- Muscles of senior women not helped by just vitamin D (also need exercise) – Aug 2019
- Muscle loss (sarcopenia) may be both prevented and treated by Omega-3 – Feb 2019
- Exercise plus vitamin D increases elderly muscles (Nordic walking in this case) – RCT Sept 2018
- Dietary Protein, Muscle and Physical Function in the Very Old – July 2018
- Postmenopausal women need Vitamin D, protein and exercise to prevent loss of muscle and bone – Aug 2018
- Sarcopenia reduction: Protein, Leucine, Omega-3, Vitamin D, and exercise - hypothesis Aug 2018
- Disability was 1.9 X more likely if weak muscles and low vitamin D two years before – Aug 2018
- Muscle problems are both treated and avoided by Vitamin D – April 2018
- Sarcopenia does not officially exist in Australia, but 1 in 3 of their seniors have it - July 2018
- Nordic Walking and 4,000 IU of vitamin D lowered cholesterol, fat, weight, and lipids (senior women) – RCT Feb 2018
- Overweight senior women with low vitamin D were 12X more likely to be weak – Feb 2018
- Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017
- Resistance exercise combined with Vitamin D is great for seniors – meta-analysis July 2017
- Fast twitch muscles increased by Vitamin D in athletes and seniors (reduce falling) – Oct 2016
- Sarcopenia: Nutrition and physical activity – systematic review – Jan 2017
- More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017
- Muscle strength of senior women increased 25 percent with vitamin D, decreased 6 percent with placebo – Oct 2016
- Senior muscles increased somewhat with Omega-3 – RCT July 2015
- Improved muscle function in postmenopausal women with just 1,000 IU of vitamin D daily – RCT May 2015
- Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014
- Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013
- Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013
- Physical performance of seniors increases with vitamin D up to 30 ng – Jan 2013
- Activity and being outdoors helps seniors – GPS and Vitamin D Dec 2012
- Type 2 muscles, not all muscles, get benefit from Vitamin D - Dec 2012
- Sarcopenia (muscle loss) and Vitamin D
- Senior women more physically able if vitamin D higher than 30 ng – Sept 2011
- Seniors with more than 20 ng of vitamin D were 14 percent stronger – May 2011
- Vitamin D2 intervention increased elderly muscle strength – Nov 2010
- Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010
Borim FSA1, Alexandre TDS2, Neri AL3, Máximo RO4, Silva MF3, de Oliveira C5.
1 Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil. flarbex at hotmail.com.
2 Department of Epidemiology and Public Health, University College London, London, United Kingdom; Dept of Gerontology, Federal University of Sao Carlos, Sao Carlos, Brazil.
3 Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
4 Department of Physical Therapy, Federal University of Sao Carlos, Sao Carlos, Brazil.
5 Department of Epidemiology and Public Health, University College London, London, United Kingdom.
BACKGROUND AND OBJECTIVE:
There is little epidemiologic evidence considering the combined effect of dynapenia and low 25-hydroxyvitamin D [25 (OH) D] on incident disability. Our aim was to investigate whether the combination of dynapenia and low 25 (OH) D serum levels increases the risk of activities of daily living (ADL) incident disability.
DESIGN: Prospective cohort study.
SETTINGS: English Longitudinal Study of Aging.
PARTICIPANTS: A total of 4630 community-dwelling adults aged 50 years and older without ADL disability at baseline.
MEASUREMENTS:
The baseline sample was categorized into 4 groups (ie, nondynapenic/normal 25 (OH) D, low 25 (OH) D only, dynapenic only, and dynapenic/low 25 (OH) D according to their handgrip strength (<26 kg for men and <16 kg for women) and 25 (OH) D (≤50 nmol/L). The outcome was the presence of any ADL disability 2 years after baseline according to the modified Katz Index. Incidence rate ratios (IRRs) adjusted by sociodemographic, behavioral, and clinical characteristics were estimated using Poisson regression.
RESULTS:
The fully adjusted model showed that older adults with dynapenia only and those with lower serum levels of 25 (OH) D combined with dynapenia had higher incident ADL disability risk compared with nondynapenic and those with normal serum levels of 25 (OH) D. The IRRs for lower 25 (OH) D serum levels combined with dynapenia were higher than for dynapenia only, however, the confidence intervals (CIs) showed similar effect for these 2 groups. The IRRs were 1.31 for low 25(OH) D only (95% CI 0.99-1.74), 1.77 for dynapenia only (95% CI 1.08-2.88), and 1.94 for combined dynapenia and low 25(OH)D (95% CI 1.28-2.94).
CONCLUSIONS:
Dynapenia only and dynapenia combined with low 25 (OH) D serum levels were important risk factors for ADL disability in middle-aged individuals and older adults in 2 years of follow-up.
PMID: 30077597 DOI: 10.1016/j.jamda.2018.06.006