Intermittent high-dose vitamin D prophylaxis during infancy: effect on vitamin D metabolites, calcium, and phosphorus.

Am J Clin Nutr. 1987 Oct;46(4):652-8.
Markestad T, Hesse V, Siebenhuner M, Jahreis G, Aksnes L, Plenert W, Aarskog D.
Department of Pediatrics, University of Bergen, Norway.

In infants receiving intermittent high dose vitamin D prophylaxis (600,000 IU ergocalciferol per dose orally) every 3-5 mo, the serum concentrations of vitamin D metabolites, calcium (Ca), and phosphorus (P) were determined before and 2 wk after each dose. The 25-hydroxyvitamin D (OHD) concentrations increased to well above normal but the values returned to the normal range before each subsequent dose. The 24,25- and 25,26-dihydroxyvitamin D ([OH]2D) levels followed a pattern similar to that of 25-OHD, and both were closely related to the latter (r = 0.85, p less than 0.005, and r = 0.84, p less than 0.005, respectively). The 1,25-(OH)2D concentrations did not vary in a consistent pattern and remained largely within the normal range. All infants had normal Ca levels before the first dose but 14 infants (34%) later had one or both Ca values above the upper normal limit of 2.80 mmol/L (2.81-3.32 mmol/L), indicating that the vitamin D doses were excessive despite the lack of accumulative increases in serum vitamin D concentrations.

PMID: 3499065

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This study was cited 101 times in Google Scholar as of July 2020

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Four reasons why this is a poor example for high dose vitamin D

1. Totally missed taking the co-factors – and probably had too much Calcium
2. 4 Months is too long a time between doses, even for D3, and vitamin D2 decays away more quickly
   The body gets very unbalanced by the huge fluctuations in Vitamin D levels
3. Vitamin D2 is not nearly as good as Vitamin D3
4. Far too large of a dose - even if considered as a daily average

600,000 IU over 90 days {actually 60 to 150 days} = 6,000 IU daily average = way too much for infants

See also Vitamin D Life

• All Megadose vitamin D items 154 items
• 300,000 IU every 3 months helped raise vitamin D levels in half of RA patients – April 2012
  they used D3, but because of no co-factors, found no improvement in bone
• 600,000 IU vitamin D normalized virtually all seniors in 3 months (Injection better than oral)– May 2012
• Overview Vitamin D3 not D2
• Take vitamin D3 daily or weekly has the following chart

• Low cost co-factors for vitamin D
• Vitamin D Recommendations from around the world
  • example: IoM 600 IU minimum and 1000 IU up to 6 months (10kg) and 1500 IU up to 12 months (15kg)
• Overview Moms babies and vitamin D
• Infants getting 1400 IU vitamin D weekly grew better – May 2011
• All items in category Pregnancy and vitamin D 750 items
• Infants getting 500 IU achieved 60 ng vitamin D in blood – Jan 2011 RCT
• Turkey gave 400 IU vitamin D to needy infants and reduced Rickets by 60X - 2011
• 600000 IU dose raised youth vitamin D level by 60 ng in 3 days – July 2010
• Overview Loading of vitamin D which includes the following chart

See also: Vitamin D Council on ALL German Infants getting 600,000 IU of vitamin D2 three times a year.

• The difference between two “normals” March 2012
  none got clinically toxic. In fact, the authors reported, “All the infants appeared healthy . . .”

3,000,000 children = about 150,000 births per year X 20 years
18,000,000 doses = children X 6

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