Hypothesis – Fatigue the day after sex is due to deficiency of Vitamin D, Magnesium, and Zinc

Most of the WikiPedia list of causes of ED are also associated with low vitamin D

• Drugs (anti-depressants (SSRIs) and nicotine are most common)
• Neurogenic disorders (spinal cord and brain injuries, nerve disorders such as
  • Parkinson's disease, Alzheimer's disease, multiple sclerosis, and stroke)
• Cavernosal disorders (Peyronie's disease)
• Psychological causes: performance anxiety, stress, mental disorders
  clinical depression, schizophrenia, substance abuse, panic disorder, generalized anxiety disorder,
  personality disorders or traits), psychological problems, negative feelings.
• Surgery (radiation therapy, surgery of the colon, prostate, bladder, or rectum may damage the nerves and blood vessels involved in erection.
  Prostate and bladder cancer surgery often require removing tissue and nerves surrounding a tumor, which increases the risk for impotence8)
• Ageing. It is four times higher in men in their 60s than in men in their 40s.
• Kidney failure
• Diseases such as diabetes and multiple sclerosis (MS).
  While these two causes have not been proven they’re likely suspects as they cause issues with both the blood flow and nervous systems.
• Lifestyle: smoking is a key cause of erectile dysfunction.
  Smoking causes impotence because it promotes arterial narrowing. See also Tobacco and health.

MS and ED

ED helped by LEVITRA which contains magnesium stearate

Clips from Dr. Sorenson– 2008

“In 1939, Dr. Abraham Myerson measured initial levels of circulating testosterone in men and exposed their various body parts to UVB light. After five days of chest exposure sufficient to cause reddening, circulating testosterone increased by 120%. After eight days without additional UV exposure, testosterone returned to initial levels. When the genital area was exposed, testosterone levels increased by 200%!”

“If vitamin D increases fertility, conception rates should be higher in summer than in winter. In higher latitude countries, where UVB availability varies dramatically during the year, conception rates are indeed at their highest in late summer and birth rates are highest the following spring.
Vitamin D levels are exceptionally low in people with chronic kidney disease, and sufferers generally experience sexual problems, including erectile dysfunction in men, decreased libido and fertility in both sexes, and menstrual abnormalities in women. Whether vitamin D is responsible or simply a result of kidney disease is not known.”

Interventions for treating sexual dysfunction in patients with chronic kidney disease.

Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007747.
Vecchio M, Navaneethan SD, Johnson DW, Lucisano G, Graziano G, Saglimbene V, Ruospo M, Querques M, Jannini EA, Strippoli GF.
Clinical Pharmacology and Epidemiology, Mario Negri Sud Consortium, Via Nazionale 8/A, Santa Maria Imbaro, Chieti, Italy, 66030.

BACKGROUND: Sexual dysfunction is very common in patients with chronic kidney disease (CKD), but it is still significantly understudied.
Treatment options exist but concerns have been raised relating to their efficacy and safety in CKD.

OBJECTIVES: We assessed the benefits and harms of existing interventions for treatment of sexual dysfunction in patients with CKD.

SEARCH STRATEGY: In October 2010 we searched the Cochrane Renal Group's specialised register, CENTRAL (The Cochrane Library, issue 10), MEDLINE (from 1966) and EMBASE (from 1980).

SELECTION CRITERIA: Randomised controlled trials (RCTs) and quasi-RCTs of any pharmacological and non-pharmacological interventions used to treat sexual dysfunction in male and female CKD patients (predialysis, dialysis and kidney transplant) were included.

DATA COLLECTION AND ANALYSIS: Two authors independently selected eligible studies, extracted data and assessed study quality. Disagreements were resolved in consultation with an arbitrator. Treatment effects were summarised as risk ratios (RR), mean differences (MD) or standardised mean difference (SMD) with 95% confidence intervals (CI) using a random-effects model.

MAIN RESULTS: Fifteen studies (8 parallel, 7 crossover; 352 patients) were included.
Only one study enrolled women. Studies evaluated the effects of

• phosphodiesterase-5 inhibitors (PDE5i),
• zinc,
• vitamin E,
• vitamin D or
• bromocriptine

compared to placebo. PDE5i significantly increased the overall International Index of Erectile Function-5 (IIEF-5) score (2 studies, 101 patients, MD 10.65, 95% CI 5.34 to 15.96), all its individual domains and the complete 15-item IIEF tool (1 study, 41 patients, MD 2.64, 95% CI 1.32 to 3.96).

End of treatment testosterone levels were not significantly increased by addition of zinc to dialysate (2 studies, 22 patients, MD 0.21 ng/mL, 95% CI -2.14 to 2.55) but oral zinc improved end of treatment testosterone levels (1 study, 20 patients, SMD 1.62, 95% CI 0.58 to 2.66).

There was no difference in plasma luteinizing and follicle-stimulating hormone levels at the end of the study period with zinc therapy.

Only sparse data were available for vitamin E, bromocriptine and dihydroxycholecalciferol in CKD patients and there were no studies of intracavernous injections, transurethral injections, mechanical devices or psychosexual therapies in people with CKD.

AUTHORS' CONCLUSIONS: PDE5i and zinc are promising interventions for treating sexual dysfunction in men with CKD. Evidence supporting their routine use in CKD patients is limited. There is an unmet need for studying interventions for both male and female sexual dysfunction in CKD, considering the significant disease burden.
PMID: 21154382
– – – –
Strange – Vitamin D was mentioned in their list the studies, but Vitamin D was not in their results

On the web

• Erectile dysfunction: a disease marker for cardiovascular disease – Jan 2011
• (pelvic) Surgery and erectile dysfunction – Oct 2010
• Managing the adverse effects of radiation therapy Aug 2010
  • Clip “Sexual dysfunction from radiation therapy includes erectile dysfunction and vaginal stenosis..”
• Erectile dysfunction as a complication of heart failure -Dec 2010 Heart failure, along with many other diseases, is known to reduce vitamin D levels.
• Both vardenafil and sildenafil (Viagraa) contain magnesium stearate
• http://poiscenter.com/forums/index.php Post Orgasmic Illness Syndrome] - which includes severe pain lasting many days
  Many forum comments on Zinc and Magnesium - along with many many other things
• ED Risk Factors

Many risk factors which were listed above are associated with low vitamin D

• Obesity
• Diabetes
• Atherosclerosis
  • Note: Vitamin D might deal with atherosclerosis – Jan 2011
• Depression
• Prostate surgery
• Smoking
• Penile injury

See also Vitamin D Life

• Magnesium is more than a co-factor for vitamin D
• Magnesium and vitamin D
  • which includes reasons for Magnesium deficiency
• Vitamin D Life Overview on Kidney and Vitamin D
• Testosterone increased with daily 3332 IU vitamin D – Dec 2010
• Higher vitamin D and 2X higher testosterone in summer than winter – Aug 2010
• More vitamin D associated with better sperm – May 2011
• Hypothesis: increased vitamin D will increase erections and decrease CVD – June 2012 by Dr. Dr. Sorenson (above) and Dr. Grant

PubMed Search for ("vitamin d" (testosterone OR androgen))
got 1071 items Jan 2016

• Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes.
• Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
• Vitamin D deficiency and fatigue: an unusual presentation. - free PDF
• Plausible ergogenic effects of vitamin D on athletic performance and recovery. - free PDF
• Vitamin D supplementation and testosterone concentrations in male human subjects.
• Serum 25-hydroxyvitamin D levels and testosterone deficiency in middle-aged Korean men: a cross-sectional study.- free PDF
• Effect of vitamin D supplementation on testosterone levels in men.
• Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men.
• Serum 25-hydroxyvitamin D concentration and physical function in adult men.

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