Nutr Rev. 2020 Jul 17;nuaa081. doi: 10.1093/nutrit/nuaa081
Fatemeh Hadizadeh 1
- This study recommends having 30-50 ng of vitamin D and achieving the goal in 2 months with 50,000 IU weekly
- However, it appears that > 40 ng of vitamin D is needed, which can be achieved with 50,000 IU daily for a week, which would then be followed by 50,000 weekly
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The coronavirus disease 2019 (COVID-19) pandemic was declared a public health emergency of international concern by the World Health Organization. COVID-19 has high transmissibility and could result in acute lung injury in a fraction of patients. By counterbalancing the activity of the renin-angiotensin system, angiotensin-converting enzyme 2, which is the fusion receptor of the virus, plays a protective role against the development of complications of this viral infection. Vitamin D can induce the expression of angiotensin-converting enzyme 2 and regulate the immune system through different mechanisms. Epidemiologic studies of the relationship between vitamin D and various respiratory infections were reviewed and, here, the postulated mechanisms and clinical data supporting the protective role of vitamin D against COVID-19-mediated complications are discussed.